Extensive crescent formation with antifibrinolytic therapy in a case of diffuse endocapillary glomerulonephritis

G.R. Foster; D.J.S. Carmichael; A. Kermode; B. Hulme; J.R.T. Gabriel; V. Cattell

doi:10.1093/ndt/5.2.152

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Extensive crescent formation with antifibrinolytic therapy in a case of diffuse endocapillary glomerulonephritis

Journal article

Peer reviewed

Extensive crescent formation with antifibrinolytic therapy in a case of diffuse endocapillary glomerulonephritis

G.R. Foster, D.J.S. Carmichael, A. Kermode, B. Hulme, J.R.T. Gabriel and V. Cattell

Nephrology Dialysis Transplantation, Vol.5(2), pp.152-154

1990

DOI: https://doi.org/10.1093/ndt/5.2.152

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Abstract

Tranexamic acid is an antifibrinolytic drug used to reduce bleeding in hyperfibrinolytic states. It has also been used in haematologically normal patients with menorrhagia, subarachnoid haemorrhage or other serious bleeding. In a variety of animal models experimental nephritis may be exacerbated by the administration of antifibrinolytic agents similar to tranexamic acid, but this has not been reported in humans in association with the drug. We have recently managed a patient with acute glomerulonephritis in whom immunological glomerular injury appears to have been exacerbated by concomitant tranexamic acid therapy.

Details

Title: Extensive crescent formation with antifibrinolytic therapy in a case of diffuse endocapillary glomerulonephritis
Authors/Creators: G.R. Foster (Author/Creator) - Renal Unit, St Mary's HospitalLondon
D.J.S. Carmichael (Author/Creator) - Renal Unit, St Mary's HospitalLondon
A. Kermode (Author/Creator) - Renal Unit, St Mary's HospitalLondon
B. Hulme (Author/Creator) - Renal Unit, St Mary's HospitalLondon
J.R.T. Gabriel (Author/Creator) - Renal Unit, St Mary's HospitalLondon
V. Cattell (Author/Creator) - Department of Histopathology, St Mary's HospitalLondon
Publication Details: Nephrology Dialysis Transplantation, Vol.5(2), pp.152-154
Publisher: Oxford University Press
Identifiers: 991005541289807891
Copyright: 1990 European Dialysis and Transplant Association-European Renal Association
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.55 Urology & Nephrology - General; 1.55.820 Nephrotic Syndrome
Web Of Science research areas: Transplantation; Urology & Nephrology
ESI research areas: Clinical Medicine