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Journal article
Extensive variation between chromosomes of North American and European hop
Nature communications, Vol.17(1), 4110
2026
PMID: 42204144
Abstract
Hop is an essential ingredient in brewing, providing beer with its characteristic bitterness and aroma. Most modern hop cultivars are hybrids between European and North American hop lineages, but how these ancestries contribute to bitter acid content, the most important trait in hop breeding, remains unclear. Here, we report chromosome-scale, haplotype-resolved assemblies of the hybrid hop cultivar Apollo, assign European and North American ancestry across the genome, and identify varying levels of recombination suppression between chromosomes of either origin. Using this reference, we uncover genetic and chemical diversity in core bittering pathways between European and North American hops. We further show additive effects of beneficial European and North American alleles on bitter acid content, providing a foundation for genomics-assisted hop breeding.
Details
- Title
- Extensive variation between chromosomes of North American and European hop
- Authors/Creators
- Sandip Mallikarjun Kale - Aarhus University (Denmark)Heidrun Gundlach - Helmholtz Zentrum MünchenOliver Gericke - Carlsberg LaboratoryNadia Kamal - Helmholtz Zentrum MünchenAldo Almeida - Carlsberg LaboratoryNicholi Pitra - Karl Landsteiner SocietyNicholas Price - Karl Landsteiner SocietyGeorg Haberer - Helmholtz Zentrum MünchenThomas Lux - Helmholtz Zentrum MünchenFlavia Krsticevic - Carlsberg LaboratoryOliver Kemp - Carlsberg LaboratoryLouise de Bang - Carlsberg LaboratoryAxel Himmelbach - Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)Sudharsan Padmarasu - Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)Mark-Timothy Rabanus-Wallace - Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)Lucie Horáková - Czech Academy of Sciences, Institute of BiophysicsVáclav Bačovský - Czech Academy of Sciences, Institute of BiophysicsKasper Nielsen - Carlsberg LaboratoryNanna Bjarnholt - University of CopenhagenNikola Micic - University of CopenhagenIsabella Kruse-Andersen - University of CopenhagenBirger Lindberg Møller - University of CopenhagenChristian Janfelt - University of CopenhagenBirgitte Skadhauge - Carlsberg LaboratoryPaul D Matthews - Karl Landsteiner SocietyKlaus F X Mayer - Helmholtz Zentrum MünchenNils Stein - Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)Martin Mascher - Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)Manuel Spannagl - Helmholtz Zentrum MünchenAlexander Feiner - HOPE ClinicIlka Braumann - Carlsberg Laboratory
- Publication Details
- Nature communications, Vol.17(1), 4110
- Publisher
- Springer Nature
- Number of pages
- 26
- Grant note
- ID AZ-1577-22 / Bayerische Forschungsstiftung (Bavarian Research Foundation) CF14-0214 / Carlsbergfondet (Carlsberg Foundation) DFF - 4002-00391 / Det Frie Forskningsråd (Danish Council for Independent Research) grant no. 19151 / Villum Fonden (Villum Foundation)
- Identifiers
- 991005888554407891
- Copyright
- © The Author(s) 2026
- Murdoch Affiliation
- Centre for Crop and Food Innovation
- Language
- English
- Resource Type
- Journal article
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