Journal article
Facilitating laser Doppler measurements of cutaneous adrenergic vasoconstriction: a comparison of methods
Clinical Autonomic Research, Vol.11(2), pp.93-98
2001
Abstract
Detecting vasoconstriction in the skin of the human forearm is often difficult because cutaneous perfusion is usually low, even in the absence of vasoconstrictive agents. However, flow through "vasoconstricted" skin can be detected by increasing the background skin blood flow. The aim of the current study was to evaluate local warming and postocclusive reactive hyperemia as techniques for increasing background flow to facilitate laser Doppler measurements of cutaneous vasoconstriction in the forearm. Noradrenaline introduced by iontophoresis into the forearm of healthy volunteers initially reduced the peak hyperemic response (mean decrease in hyperemia 21 ± 7%, p <0.01), compared with a saline control. However, vasoconstriction was unrelated to the dose of noradrenaline and was not detectable when the test was repeated, possibly because the peak of the normal hyperemic response decreased with repeated occlusions. When the forearm was warmed to 42°C, noradrenaline introduced by iontophoresis produced dose-dependent vasoconstriction relative to saline control sites and skin not having undergone iontophoresis (greatest mean decrease 64 ± 7%, p <0.001). Therefore, local warming is recommended over reactive hyperemia for facilitating laser Doppler recordings of cutaneous vasoconstriction in the human forearm.
Details
- Title
- Facilitating laser Doppler measurements of cutaneous adrenergic vasoconstriction: a comparison of methods
- Authors/Creators
- D.M. Lipnicki (Author/Creator) - Murdoch UniversityP.D. Drummond (Author/Creator) - Murdoch University
- Publication Details
- Clinical Autonomic Research, Vol.11(2), pp.93-98
- Publisher
- Springer
- Identifiers
- 991005541605907891
- Copyright
- Lippincott Williams & Wilkins
- Murdoch Affiliation
- School of Psychology
- Language
- English
- Resource Type
- Journal article
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- Web Of Science research areas
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