Journal article
Factors Associated with Outcome in Foals with Neonatal Isoerythrolysis (72 Cases, 1988-2003)
Journal of Veterinary Internal Medicine, Vol.22(5), pp.1216-1222
2008
Abstract
Background: Neonatal foals with isoerythrolysis (NI) often die, but the risk factors for death have not been identified.
Objectives: To identify factors associated with outcome in foals with NI and to identify factors associated with death from liver failure or kernicterus in the same population.
Animals: Seventy-two foals with NI examined at referral institutions.
Methods: Retrospective case series. Information on signalment, clinical examination findings, laboratory testing, treatment, complications, outcome, and necropsy results were obtained.
Results: The overall survival rate was 75% (54 of 72). Liver failure (n = 7), kernicterus (n = 6), and complications related to bacterial sepsis (n = 3) were the 3 most common reasons for death or euthanasia. The number of transfusions with blood products was the factor most strongly associated with nonsurvival in a multivariate logistic regression model. The odds of liver failure developing in foals receiving a total volume of blood products ≥ 4.0 L were 19.5 (95% confidence intervals [CI]: 2.13–178) times higher than that of foals receiving a lower volume (P= .009). The odds of kernicterus developing in foals with a total bilirubin ≥ 27.0 mg/dL were 17.0 (95% CI: 1.77–165) times higher than that of foals with a lower total bilirubin (P= .014).
Conclusions and Clinical Importance: Development of liver failure, kernicterus, and complications related to bacterial sepsis are the most common causes of death in foals with NI. Foals administered a large volume of blood products are at greater risk for developing liver failure.
Details
- Title
- Factors Associated with Outcome in Foals with Neonatal Isoerythrolysis (72 Cases, 1988-2003)
- Authors/Creators
- A.C. Polkes (Author/Creator) - University of FloridaS. Giguère (Author/Creator) - University of FloridaG.D. Lester (Author/Creator) - Murdoch UniversityF.T. Bain (Author/Creator) - Hagyard Equine Medical Institute
- Publication Details
- Journal of Veterinary Internal Medicine, Vol.22(5), pp.1216-1222
- Publisher
- American College of Veterinary Internal Medicine
- Identifiers
- 991005544651807891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
30 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.51 Dairy & Animal Sciences
- 3.51.2057 Colostrum
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science