Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of North West Australia

J.A. Reynoldson; J.M. Behnke; L.J. Pallant; M.G. Macnish; F. Gilbert; S. Giles; R.J. Spargo; R.C.A. Thompson

doi:10.1016/S0001-706X(97)00106-X

Back

Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of North West Australia

Journal article

Peer reviewed

Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of North West Australia

J.A. Reynoldson, J.M. Behnke, L.J. Pallant, M.G. Macnish, F. Gilbert, S. Giles, R.J. Spargo and R.C.A. Thompson

Acta Tropica, Vol.68(3), pp.301-312

1997

DOI: https://doi.org/10.1016/S0001-706X(97)00106-X

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

A survey of 108 individuals from a coastal Aboriginal community in north Western Australia revealed that two species of gastrointestinal protozoan parasites (Giardia duodenalis-39.8%, Entamoeba coli - 40.7%) and five gastrointestinal helminths (Hymenolepis nana - 54.6%, Hookworm [Ancylostoma duodenale] - 30.6%, Enterobius vermicularis - 6.5%, Trichuris trichiura - 2.8%, Strongyloides stercoralis 1.9%) were present. A total of 29 individuals infected with hookworm were offered treatment with either pyrantel pamoate at a single dose rate of 10 mg/kg body weight or albendazole (single 400 mg dose). Seven days after treatment stool samples were examined. Pyrantel had no significant effect against hookworm. In contrast, albendazole cleared hookworm infections completely and reduced the prevalence of Giardia. The former result suggests that locally A. duodenale is resistant to pyrantel and despite its relatively low cost and wide availability, should not be considered a drug of choice at this dose rate in the treatment of hookworm infections (A. duodenale) in endemic regions.

Details

Title: Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of North West Australia
Authors/Creators: J.A. Reynoldson (Author/Creator)
J.M. Behnke (Author/Creator)
L.J. Pallant (Author/Creator)
M.G. Macnish (Author/Creator)
F. Gilbert (Author/Creator)
S. Giles (Author/Creator)
R.J. Spargo (Author/Creator)
R.C.A. Thompson (Author/Creator)
Publication Details: Acta Tropica, Vol.68(3), pp.301-312
Publisher: Elsevier BV
Identifiers: 991005544997807891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

44 Record Views

132 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.446 Schistosomiasis
Web Of Science research areas: Parasitology; Tropical Medicine
ESI research areas: Clinical Medicine