Failure to infect laboratory rodent hosts with human isolates of Rodentolepis (= Hymenolepis) nana

M. Macnish; U.M. Morgan; J.M. Behnke; R.C.A. Thompson

doi:10.1079/JOH200198

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Failure to infect laboratory rodent hosts with human isolates of Rodentolepis (= Hymenolepis) nana

Journal article

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Failure to infect laboratory rodent hosts with human isolates of Rodentolepis (= Hymenolepis) nana

M. Macnish, U.M. Morgan, J.M. Behnke and R.C.A. Thompson

Journal of Helminthology, Vol.76(1), pp.37-43

2002

DOI: https://doi.org/10.1079/JOH200198

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Abstract

Confusion exists over the species status and host-specificity of the tapeworm Rodentolepis (= Hymenolepis) nana. It has been described as one species, R. nana, found in both humans and rodents. Others have identified a subspecies; R. nana var. fraterna, describing it as morphologically identical to the human form but only found in rodents. The species present in Australian communities has never been identified with certainty. Fifty one human isolates of Rodentolepis (= Hymenolepis) nana were orally inoculated into Swiss Q, BALB/c, A/J, CBA/CAH and nude (hypothymic) BALB/c mice, Fischer 344 and Wistar rats and specific pathogen free (SPF) hamsters. Twenty four human isolates of R. nana were cross-tested in flour beetles, Tribolium confusum. No adult worms were obtained from mice, rats or hamsters, even when immunosuppressed with cortisone acetate. Only one of the 24 samples developed to the cysticercoid stage in T. confusum; however, when inoculated into laboratory mice the cysticercoids failed to develop into adult worms. The large sample size used in this study, and the range of techniques employed for extraction and preparation of eggs provide a comprehensive test of the hypothesis that the human strain of R. nana is essentially non-infective to rodents.

Details

Title: Failure to infect laboratory rodent hosts with human isolates of Rodentolepis (= Hymenolepis) nana
Authors/Creators: M. Macnish (Author/Creator) - Murdoch University
U.M. Morgan (Author/Creator) - Murdoch University
J.M. Behnke (Author/Creator)
R.C.A. Thompson (Author/Creator)
Publication Details: Journal of Helminthology, Vol.76(1), pp.37-43
Publisher: Cambridge University Press
Identifiers: 991005539584907891
Copyright: © CAB International, 2002
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.645 Fish Parasitology
Web Of Science research areas: Parasitology; Zoology
ESI research areas: Plant & Animal Science