Journal article
FcγRIIb expression is decreased on naive and marginal Zone-Like B Cells from females with multiple sclerosis
Frontiers in Immunology, Vol.11, Art. 614492
2021
Abstract
B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory activities in B cells, is lower on B cell subsets from people with clinically isolated syndrome (CIS) or MS. CD32b expression was highest on post-naive IgM+ B cell subsets in healthy controls. For females with MS or CIS, significantly lower CD32b expression was identified on IgM+ B cell subsets, including naive and IgMhi MZ-like B cells, when compared with control females. Lower CD32b expression on these B cell subsets was associated with detectable anti-Epstein Barr Virus viral capsid antigen IgM antibodies, and higher serum levels of B cell activating factor. To investigate the effects of lower CD32b expression, B cells were polyclonally activated in the presence of IgG immune complexes, with or without a CD32b blocking antibody, and the expression of TNF and IL-10 in B cell subsets was assessed. The reduction of TNF but not IL-10 expression in controls mediated by IgG immune complexes was reversed by CD32b blockade in naive and IgMhi MZ-like B cells only. However, no consequence of lower CD32b expression on these cells from females with CIS or MS was detected. Our findings highlight a potential role for naive and marginal zone-like B cells in the immunopathogenesis of MS in females, which requires further investigation.
Details
- Title
- FcγRIIb expression is decreased on naive and marginal Zone-Like B Cells from females with multiple sclerosis
- Authors/Creators
- S. Trend (Author/Creator) - Perron Institute for Neurological and Translational ScienceJ. Leffler (Author/Creator) - The Kids Research Institute AustraliaI. Teige (Author/Creator) - BioInvent (Sweden)B. Frendéus (Author/Creator) - BioInvent (Sweden)A.G. Kermode (Author/Creator) - Murdoch UniversityM.A. French (Author/Creator) - The University of Western AustraliaP.H. Hart (Author/Creator) - The Kids Research Institute Australia
- Publication Details
- Frontiers in Immunology, Vol.11, Art. 614492
- Publisher
- Frontiers Media
- Identifiers
- 991005544611407891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology