Journal article
Feline Idiopathic Cystitis: Pathogenesis, Histopathology and Comparative Potential
Journal of Comparative Pathology, Vol.185, pp.18-29
2021
Abstract
Bladder pain syndrome (BPS) is a debilitating disease in humans, particularly women, with patients experiencing chronic, intractable, lower urinary and pelvic pain. Although rodent models have been used, feline idiopathic cystitis (FIC) is a naturally occurring bladder disease of cats that is frequently considered to be the preferred model for BPS. Histologically, FIC is most similar to the non-Hunner BPS subtype. Histology is unnecessary for the clinical diagnosis of FIC but is of great value in elucidating the pathogenesis of this disease so that prevention and therapeutic interventions can be optimized. Further study of the histological features of FIC and BPS is required to determine the significance of Von Brunn's nests, which are invaginations of hyperplastic urothelium that have been associated with irritative bladder stimuli in animals and have been observed in FIC. We review the possible pathogenesis, histopathological similarities and differences between FIC and BPS, and highlight the potential of FIC as a model of BPS.
Details
- Title
- Feline Idiopathic Cystitis: Pathogenesis, Histopathology and Comparative Potential
- Authors/Creators
- E. Jones (Author/Creator)C. Palmieri (Author/Creator)M. Thompson (Author/Creator)K. Jackson (Author/Creator)R. Allavena (Author/Creator)
- Publication Details
- Journal of Comparative Pathology, Vol.185, pp.18-29
- Publisher
- Elsevier BV
- Identifiers
- 991005544876107891
- Copyright
- © 2021 Elsevier Ltd.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.142 Urology
- 1.142.165 Pelvic Floor Disorders
- Web Of Science research areas
- Pathology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science