Journal article
Fibrosing mediastinitis complicating prior histoplasmosis is associated with human leukocyte antigen DQB1*04:02 − a case control study
BMC Infectious Diseases, Vol.15(1)
2015
Abstract
Background
Fibrosing mediastinitis (FM) is an idiosyncratic reaction to infection with Histoplasma capsulatum with a prevalence of 3:100,000 people infected. The rarity of post-histoplasmosis fibrosing mediastinitis (PHFM) in areas where H. capsulatum is endemic suggests that an abnormal immunological host response may be responsible for the development of fibrosis. Our group previously reported an association between subjects with PHFM and human leukocyte antigen (HLA)-A*02. We sought to confirm or extend those findings with application of high resolution HLA typing in a cohort of subjects with PHFM.
Methods
High-resolution HLA typing was performed on DNA samples from a new cohort 34 patients with PHFM. Control cohorts included 707 subjects from the “European American” subset of the National Marrow Donor Program® (NMDP) and 700 subjects from Dialysis Clinic, Inc. (DCI). The carriage frequencies of the HLA alleles identified in the PHFM, NMDP, and DCI cohorts were calculated and then all were compared.
Results
We found an increase in the carriage frequency of HLA-DQB1*04:02 in PHFM subjects relative to the controls (0.15 versus 0.07 in DCI and 0.05 in NMDP; p = 0.08 and 0.03). Multiple logistic regression showed that DQB1*04:02 was statistically significant (p = 0.04), while DQB1*03:02 and C*03:04 had point estimates of OR > 1, though they did not reach statistical significance. The HLA-A*02 association was not replicated.
Conclusions
HLA-DQB1*04:02 is associated with PHFM, which supports the premise that an aberrant host immune response contributes to the development of PHFM.
Details
- Title
- Fibrosing mediastinitis complicating prior histoplasmosis is associated with human leukocyte antigen DQB1*04:02 − a case control study
- Authors/Creators
- S.B. Strock (Author/Creator) - Vanderbilt UniversityS. Gaudieri (Author/Creator) - Murdoch UniversityS. Mallal (Author/Creator) - Vanderbilt UniversityC. Yu (Author/Creator) - Vanderbilt UniversityD. Mitchell (Author/Creator) - Vanderbilt UniversityJ. Cogan (Author/Creator) - Vanderbilt UniversityW. Mason (Author/Creator) - Vanderbilt UniversityD. Crowe (Author/Creator) - DCI Laboratory – Transplant Immunology, Nashville, USAJ.E. Loyd (Author/Creator) - Vanderbilt University
- Publication Details
- BMC Infectious Diseases, Vol.15(1)
- Publisher
- BioMed Central
- Identifiers
- 991005544345607891
- Copyright
- © 2015 Strock et al.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- 1.208 Vasculitis & Autoimmune Disorders
- 1.208.1555 IgG4-Related Disease
- Web Of Science research areas
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- Immunology