Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus

D. Perera; J. Stankovich; H. Butzkueven; B.V. Taylor; S.J. Foote; T.J. Kilpatrick; J.P. Rubio

doi:10.1016/j.jneuroim.2009.03.010

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Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus

Journal article

Peer reviewed

Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus

D. Perera, J. Stankovich, H. Butzkueven, B.V. Taylor, S.J. Foote, T.J. Kilpatrick and J.P. Rubio

Journal of Neuroimmunology, Vol.211(1-2), pp.105-109

2009

DOI: https://doi.org/10.1016/j.jneuroim.2009.03.010

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Abstract

Multiple sclerosis (MS) is a genetically complex autoimmune disease. To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls. Seven newly-typed SNP variants were nominally associated with risk of MS, and one SNP (rs791589) in the first intron of the IL2RA gene remained associated after adjustment for rs2104286 genotype, a previously reported SNP association. These data provide further evidence of allelic heterogeneity at the IL2RA locus and point to the existence of at least two independent MS susceptibility alleles.

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Title: Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus
Authors/Creators: D. Perera (Author/Creator) - Menzies Research Institute
J. Stankovich (Author/Creator) - Menzies Research Institute
H. Butzkueven (Author/Creator) - Florey Institute of Neuroscience and Mental Health
B.V. Taylor (Author/Creator) - Menzies Research Institute
S.J. Foote (Author/Creator) - Menzies Research Institute
T.J. Kilpatrick (Author/Creator) - The Royal Melbourne Hospital
J.P. Rubio (Author/Creator) - Florey Institute of Neuroscience and Mental Health
Publication Details: Journal of Neuroimmunology, Vol.211(1-2), pp.105-109
Publisher: Elsevier
Identifiers: 991005543003907891
Copyright: © 2009 Elsevier B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Immunology; Neurosciences
ESI research areas: Neuroscience & Behavior