Journal article
Fine-needle aspiration biopsy for the measurement of hepatic iron concentration
Hepatology, Vol.15(3), pp.502-506
2005
Abstract
The potential application of fine-needle aspiration liver biopsy in the documentation of hepatic iron overload has been assessed in iron-loaded rats. Fineneedle aspiration and standard liver biopsy specimens were obtained from three groups of animals supplemented with oral and parenteral iron for 2 to 6 mo. The mean dry weights of standard and fine-needle biopsy specimens were 7.41 ± 0.77 (± S.E.M.) and 0.57 ± 0.54 mg, respectively. Hepatic iron in fine-needle aspiration biopsy specimens correlated significantly with hepatic iron in standard liver biopsy specimens as measured by biochemical determination, computerized image analysis and histological grading (r > 0.9, p < 0.001). In conclusion, we have shown that fine-needle aspiration biopsy of the liver can obtain sufficient tissue for biochemical measurement of the hepatic iron concentration in an animal model of iron overload. The clinical applications of fine-needle aspiration liver biopsy in human beings with iron overload is currently being investigated.
Details
- Title
- Fine-needle aspiration biopsy for the measurement of hepatic iron concentration
- Authors/Creators
- J. Olynyk (Author/Creator)P. Williams (Author/Creator)A. Fudge (Author/Creator)S. Pulbrook (Author/Creator)R. Kerr (Author/Creator)M. Mackinnon (Author/Creator)P. Hall (Author/Creator)
- Publication Details
- Hepatology, Vol.15(3), pp.502-506
- Publisher
- John Wiley & Sons Inc.
- Identifiers
- 991005545523607891
- Copyright
- © 1992 Wiley Subscription Services, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.184 Physiology & Metals
- 1.184.573 Iron Metabolism
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine