Journal article
First case of a dog infected with Aspergillus (Phialosimplex) caninus in Australasia
New Zealand Veterinary Journal
2020
Abstract
Case history: A 2-year-old Rottweiler dog from Perth (WA, Australia) was referred for assessment of a chronic productive cough and weight loss.
Clinical findings: Severely enlarged bilateral superficial cervical lymph nodes and severely enlarged abdominal organs were present. The body condition score was poor and there was moderate muscle wasting. Thoracic and abdominal computed tomography images revealed severe diffuse enlargement of thoracic and abdominal lymph nodes, hepatomegaly and diffuse splenomegaly. A diffuse bronchial pattern with severe multifocal saccular bronchiectasis was identified in the lungs.
Diagnostic findings: Fungal organisms were seen within macrophages on cytological preparations and on histopathological sections of biopsies of the superficial cervical lymph node. Macrophages contained intracytoplasmic, non-filamentous round-to-ovoid organisms, which varied in size from 5–30 µm in diameter with variable morphology. Budding was not observed, and no hyphae were present. Fungal culture of lymph node tissue resulted in growth of Aspergillus (Phialosimplex) caninus which was confirmed by amplification and sequencing of a segment of the 16S-23S rRNA internal transcribed spacer. Concurrent bacterial bronchitis was diagnosed on culture of broncho-alveolar fluid.
Diagnosis: Disseminated aspergillosis caused by Aspergillus caninus.
Clinical relevance: This is believed to be the first report of infection caused by A. caninus in a dog in Australasia. The dog was treated with itraconazole for 7 months and was still alive 7 months after the start of treatment.
Details
- Title
- First case of a dog infected with Aspergillus (Phialosimplex) caninus in Australasia
- Authors/Creators
- W. Yang (Author/Creator) - Murdoch UniversityB. R. JonesG. Rossi (Author/Creator) - Murdoch UniversityN. Stephens (Author/Creator) - Murdoch UniversityI. Arthur (Author/Creator) - Queen Elizabeth II Medical CentreA. Merritt (Author/Creator) - Queen Elizabeth II Medical CentreS. Reese (Author/Creator) - Vet Imaging Specialists, Murdoch, WA, Australia.K.F.A. Langner (Author/Creator) - Murdoch University
- Publication Details
- New Zealand Veterinary Journal
- Publisher
- New Zealand Veterinary Association
- Identifiers
- 991005543408307891
- Copyright
- © 2020 New Zealand Veterinary Association
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.148 Medical Mycology
- 1.148.94 Antifungal Strategies
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science