Journal article
Flattening the biological age curve by improving metabolic health: to taurine or not to taurine, that' s the question
Journal of geriatric cardiology : JGC, Vol.20(11), pp.813-823
2023
PMID: 38098466
Abstract
The aging population is an important issue around the world especially in developed countries. Although medical advances have substantially extended life span, the same cannot be said for the duration of health span. We are seeing increasing numbers of elderly people who are frail and/or have multiple chronic conditions; all of these can affect the quality of life of the elderly population as well as increase the burden on the healthcare system. Aging is mechanistically related to common medical conditions such as diabetes mellitus, ischemic heart disease, cognitive decline, and frailty. A recently accepted concept termed 'Accelerated Biological Aging' can be diagnosed when a person's biological age-as measured by biomarkers of DNA methylation-is older than their corresponding chronological age. Taurine, a conditionally essential amino acid, has received much attention in the past few years. A substantial number of animal studies have provided a strong scientific foundation suggesting that this amino acid can improve cellular and metabolic health, including blood glucose control, so much that it has been labelled one of the 'longevity amino acids'. In this review article, we propose the rationale that an adequately powered randomized-controlled-trial (RCT) is needed to confirm whether taurine can meaningfully improve metabolic and microbiome health, and biological age. This trial should incorporate certain elements in order to provide the much-needed evidence to guide doctors, and also the community at large, to determine whether this promising and inexpensive amino acid is useful in improving human metabolic health.
Details
- Title
- Flattening the biological age curve by improving metabolic health: to taurine or not to taurine, that' s the question
- Authors/Creators
- Kwok M Ho - The University of Western AustraliaAnna Lee - Prince of Wales HospitalWilliam Wu - Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, ChinaMatthew T V Chan - Prince of Wales HospitalLowell Ling - Prince of Wales HospitalJeffrey Lipman - Royal Brisbane and Women's HospitalJason Roberts - Royal Brisbane and Women's HospitalEdward Litton - Fiona Stanley HospitalGavin M Joynt - Prince of Wales HospitalMartin Wong - Fudan University
- Publication Details
- Journal of geriatric cardiology : JGC, Vol.20(11), pp.813-823
- Publisher
- Tsinghua University Press Ltd
- Identifiers
- 991005623667107891
- Copyright
- © 2023 JGC All rights reserved
- Murdoch Affiliation
- College of Environmental and Life Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.287 Dietary Stimulants
- 1.287.2249 Taurine
- Web Of Science research areas
- Cardiac & Cardiovascular Systems
- Geriatrics & Gerontology
- ESI research areas
- Clinical Medicine