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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Fluid biomarkers in cerebral amyloid angiopathy
Frontiers in neuroscience, Vol.18, 1347320
2024
Abstract
Cerebral amyloid angiopathy (CAA) is a type of cerebrovascular disorder characterised by the accumulation of amyloid within the leptomeninges and small/medium-sized cerebral blood vessels. Typically, cerebral haemorrhages are one of the first clinical manifestations of CAA, posing a considerable challenge to the timely diagnosis of CAA as the bleedings only occur during the later disease stages. Fluid biomarkers may change prior to imaging biomarkers, and therefore, they could be the future of CAA diagnosis. Additionally, they can be used as primary outcome markers in prospective clinical trials. Among fluid biomarkers, blood-based biomarkers offer a distinct advantage over cerebrospinal fluid biomarkers as they do not require a procedure as invasive as a lumbar puncture. This article aimed to provide an overview of the present clinical data concerning fluid biomarkers associated with CAA and point out the direction of future studies. Among all the biomarkers discussed, amyloid β, neurofilament light chain, matrix metalloproteinases, complement 3, uric acid, and lactadherin demonstrated the most promising evidence. However, the field of fluid biomarkers for CAA is an under-researched area, and in most cases, there are only one or two studies on each of the biomarkers mentioned in this review. Additionally, a small sample size is a common limitation of the discussed studies. Hence, it is hard to reach a solid conclusion on the clinical significance of each biomarker at different stages of the disease or in various subpopulations of CAA. In order to overcome this issue, larger longitudinal and multicentered studies are needed.
Details
- Title
- Fluid biomarkers in cerebral amyloid angiopathy
- Authors/Creators
- Seyed SavarBin MaEugene HoneFarzana JahanShaun MarkovicSteve PedriniSoudabeh ShemehsavarVandhana EaswaranKevin TaddeiSamantha GardenerJasmeer ChhatwalEllis van EttenMatthias J. P. van OschDaniel ClarkeAnastazija GnjecMark van BuchemMarieke WermerGraeme HankeySteven GreenbergRalph MartinsHamid Sohrabi
- Publication Details
- Frontiers in neuroscience, Vol.18, 1347320
- Publisher
- Frontiers Research Foundation
- Identifiers
- 991005632270007891
- Copyright
- © 2024 Savar, Ma, Hone, Jahan, Markovic, Pedrini, Shemehsavar, Easwaran, Taddei, Gardener, Chhatwal, van Etten, van Osch, Clarke, Gnjec, van Buchem, Wermer, Hankey, Greenberg, Martins and Sohrabi.
- Murdoch Affiliation
- Centre for Healthy Ageing; College of Science, Technology, Engineering and Mathematics; School of Psychology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior