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Journal article
Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson's disease
Brain (London, England : 1878), Vol.146(3), pp.1053-1064
2023
PMID: 35485491
Abstract
Free-water imaging can predict and monitor dopamine system degeneration in people with Parkinson's disease. It can also enhance the sensitivity of traditional diffusion tensor imaging (DTI) metrics for indexing neurodegeneration. However, these tools are yet to be applied to investigate cholinergic system degeneration in Parkinson's disease, which involves both the pedunculopontine nucleus and cholinergic basal forebrain.
Free-water imaging, free-water-corrected DTI and volumetry were used to extract structural metrics from the cholinergic basal forebrain and pedunculopontine nucleus in 99 people with Parkinson's disease and 46 age-matched controls. Cognitive ability was tracked over 4.5 years.
Pearson's partial correlations revealed that free-water-corrected DTI metrics in the pedunculopontine nucleus were associated with performance on cognitive tasks that required participants to make rapid choices (behavioural flexibility). Volumetric, free-water content and DTI metrics in the cholinergic basal forebrain were elevated in a sub-group of people with Parkinson's disease with evidence of cognitive impairment, and linear mixed modelling revealed that these metrics were differently associated with current and future changes to cognition.
Free water and free-water-corrected DTI can index cholinergic degeneration that could enable stratification of patients in clinical trials of cholinergic interventions for cognitive decline. In addition, degeneration of the pedunculopontine nucleus impairs behavioural flexibility in Parkinson's disease, which may explain this region's role in increased risk of falls.
Details
- Title
- Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson's disease
- Authors/Creators
- Nicola J Ray - Manchester Metropolitan UniversityRachael A Lawson - Newcastle UniversitySarah L Martin - Manchester Metropolitan UniversityHilmar P Sigurdsson - Newcastle UniversityJoanna Wilson - Newcastle UniversityBrook Galna - Murdoch University, Centre for Healthy AgeingSue Lord - Auckland University of TechnologyLisa Alcock - Newcastle UniversityGordon W Duncan - NHS LothianTien K Khoo - Griffith UniversityJohn T O'Brien - University of CambridgeDavid J Burn - Newcastle UniversityJohn-Paul Taylor - Newcastle UniversityRiver C Rea - Manchester Metropolitan UniversityMaurizio Bergamino - Barrow Neurological InstituteLynn Rochester - Newcastle UniversityAlison J Yarnall - Newcastle University
- Publication Details
- Brain (London, England : 1878), Vol.146(3), pp.1053-1064
- Publisher
- Oxford University Press on behalf of the Guarantors of Brain.
- Grant note
- Department of Health Wellcome Trust
- Identifiers
- 991005588666707891
- Copyright
- © 2022 The Author(s).
- Murdoch Affiliation
- Health Futures Institute
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.67 Parkinson's Disease
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior