Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study

A. Rojana-udomsart; C. Bundell; I. James; A. Castley; P. Martinez; F. Christiansen; P. Hollingsworth; F. Mastaglia

doi:10.1016/j.jneuroim.2012.04.007

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Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study

Journal article

Peer reviewed

Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study

A. Rojana-udomsart, C. Bundell, I. James, A. Castley, P. Martinez, F. Christiansen, P. Hollingsworth and F. Mastaglia

Journal of Neuroimmunology, Vol.249(1-2), pp.66-70

2012

DOI: https://doi.org/10.1016/j.jneuroim.2012.04.007

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Abstract

The frequency of myositis-associated and myositis-specific autoantibodies (AAb) was compared in 51 s-IBM patients and a population control group. Non-organ specific AAb (ANA, anti-Ro52, anti-Ro60, anti-La, anti-RNP) but not anti-thyroid peroxidase, anti-tissue transglutaminase or myositis-specific antibodies, were more frequent in s-IBM patients, and 14/51 (27%) had another autoimmune disease (Sjögren's syndrome, thyroiditis, psoriasis, vitiligo). The presence of AAb did not correlate with carriage of HLA-DRB1*0301, but there was a negative correlation between ANA/anti-Ro52 and carriage of HLA-DRB1*1301. The findings in this cohort confirm that patients with sIBM do not show evidence of a muscle-specific humoral immune process but have an increased frequency of non-organ specific AAb and other autoimmune disorders.

Details

Title: Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study
Authors/Creators: A. Rojana-udomsart (Author/Creator)
C. Bundell (Author/Creator)
I. James (Author/Creator)
A. Castley (Author/Creator)
P. Martinez (Author/Creator)
F. Christiansen (Author/Creator)
P. Hollingsworth (Author/Creator)
F. Mastaglia (Author/Creator)
Publication Details: Journal of Neuroimmunology, Vol.249(1-2), pp.66-70
Publisher: Elsevier
Identifiers: 991005542143207891
Copyright: © 2012 Elsevier B.V
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.1684 Dermatomyositis
Web Of Science research areas: Immunology; Neurosciences
ESI research areas: Neuroscience & Behavior