Journal article
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study
Journal of Neuroimmunology, Vol.249(1-2), pp.66-70
2012
Abstract
The frequency of myositis-associated and myositis-specific autoantibodies (AAb) was compared in 51 s-IBM patients and a population control group. Non-organ specific AAb (ANA, anti-Ro52, anti-Ro60, anti-La, anti-RNP) but not anti-thyroid peroxidase, anti-tissue transglutaminase or myositis-specific antibodies, were more frequent in s-IBM patients, and 14/51 (27%) had another autoimmune disease (Sjögren's syndrome, thyroiditis, psoriasis, vitiligo). The presence of AAb did not correlate with carriage of HLA-DRB1*0301, but there was a negative correlation between ANA/anti-Ro52 and carriage of HLA-DRB1*1301. The findings in this cohort confirm that patients with sIBM do not show evidence of a muscle-specific humoral immune process but have an increased frequency of non-organ specific AAb and other autoimmune disorders.
Details
- Title
- Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study
- Authors/Creators
- A. Rojana-udomsart (Author/Creator)C. Bundell (Author/Creator)I. James (Author/Creator)A. Castley (Author/Creator)P. Martinez (Author/Creator)F. Christiansen (Author/Creator)P. Hollingsworth (Author/Creator)F. Mastaglia (Author/Creator)
- Publication Details
- Journal of Neuroimmunology, Vol.249(1-2), pp.66-70
- Publisher
- Elsevier
- Identifiers
- 991005542143207891
- Copyright
- © 2012 Elsevier B.V
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Immunology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior