Journal article
Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus
Proceedings of the National Academy of Sciences, Vol.105(37), pp.14130-14135
2008
Abstract
A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable β-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene (spa) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported.
Details
- Title
- Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus
- Authors/Creators
- U. Nubel (Author/Creator)P. Roumagnac (Author/Creator)M. Feldkamp (Author/Creator)J-H Song (Author/Creator)K. S. Ko (Author/Creator)Y-C Huang (Author/Creator)G. Coombs (Author/Creator)M. Ip (Author/Creator)H. Westh (Author/Creator)R. Skov (Author/Creator)M.J. Struelens (Author/Creator)R.V. Goering (Author/Creator)B. Strommenger (Author/Creator)A. Weller (Author/Creator)W. Witte (Author/Creator)M. Achtman (Author/Creator)
- Publication Details
- Proceedings of the National Academy of Sciences, Vol.105(37), pp.14130-14135
- Publisher
- National Academy of Sciences
- Identifiers
- 991005545299307891
- Copyright
- © 2008 by The National Academy of Sciences of the USA.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
29 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology