Logo image
Back
Functional and morphological studies on blood platelets in a thrombasthenic horse
Journal article   Peer reviewed

Functional and morphological studies on blood platelets in a thrombasthenic horse

R.J. Sutherland, H. Cambridge and J.R. Bolton
Australian Veterinary Journal, Vol.66(11), pp.366-370
1989
DOI: https://doi.org/10.1111/j.1751-0813.1989.tb09735.x
url
Link to Published Version *Subscription may be requiredView

Abstract

A four-year-old Standardbred gelding presented with a 3.5 year history of intermittent epistaxis and spontaneous submucosal petechiae and ecchymoses in the nares and the mouth. Routine haematological and biochemical examinations were unremarkable. A thrombocytopathy was suspected when activated partial thromboplastin time, one stage prothrombin time, plasma fibrinogen and the platelet count were all normal. The patient's platelets failed to aggregate with serotonin, adenosine diphosphate, collagen (at 20μg/ml) or the endoperoxide analogue U46619. Very high levels of collagen (100μg/ml) did cause aggregation. The response to the calcium ionophore A23187 was reduced and although complete degranulation occurred the resulting aggregates were unstable. Thromboxane generation in response to collagen and ADP was inferred from the concentration of its stable metabolite thromboxane B2 and was reduced. A diagnosis of a thrombasthenia-like syndrome possibly equivalent to Type II Glanzmann's thrombasthenia in people was made.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Metrics

35 Record Views
11 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Citation topics
1 Clinical & Life Sciences
1.75 Blood Clotting
1.75.619 Bleeding Disorders
Web Of Science research areas
Veterinary Sciences
ESI research areas
Plant & Animal Science
Logo image