Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers

S. Lau; K.A. Bates; H.R. Sohrabi; M. Rodrigues; G. Martins; S.S. Dhaliwal; K. Taddei; S.M. Laws; I.. Martins; F.L. Mastaglia; J.K. Foster; J.K. Phillips; R.N. Martins

doi:10.1016/j.neurobiolaging.2010.09.003

Back

Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers

Journal article

Peer reviewed

Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers

S. Lau, K.A. Bates, H.R. Sohrabi, M. Rodrigues, G. Martins, S.S. Dhaliwal, K. Taddei, S.M. Laws, I.. Martins, F.L. Mastaglia, …

Neurobiology of Aging, Vol.33(6), pp.1054-1056

2012

DOI: https://doi.org/10.1016/j.neurobiolaging.2010.09.003

Files and links (2)

url

Link to Published Version *Subscription may be requiredView

url

Free to Read *No subscription requiredView

Abstract

A number of genetic risk factors have been identified for Alzheimer's disease (AD) including genes involved in the inflammatory response (interleukin 1A, [IL-1 alpha (-889)], interleukin 1B (IL-1 beta [+3953]), and tumor necrosis factor (TNF [-308 and -850]). We investigated the prevalence and functional consequences (baseline cognitive performance, plasma cytokine levels) of possession of these putative genetic risk factors within a group of subjective memory complainers (SMC, n = 226) and age and sex matched noncomplainers (NMC, n = 167). We observed no effect of any of the genetic factors investigated on cognitive performance. Further, there was no difference in the frequency of the disease-associated alleles, or cytokine levels between subjective memory complainers and noncomplainer participants. There was no relationship between TNF polymorphisms and TNF levels. There was a significant increase in plasma IL-1 beta levels in those homozygous for the disease-associated allele (i.e., IL-1 beta +3953 TT). Follow-up longitudinal assessments on this cohort will provide insight as to how these polymorphisms may affect the risk of cognitive decline over time.

Details

Title: Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers
Authors/Creators: S. Lau (Author/Creator) - Edith Cowan University
K.A. Bates (Author/Creator) - The University of Western Australia
H.R. Sohrabi (Author/Creator) - The University of Western Australia
M. Rodrigues (Author/Creator) - Edith Cowan University
G. Martins (Author/Creator) - Edith Cowan University
S.S. Dhaliwal (Author/Creator) - Curtin University
K. Taddei (Author/Creator) - Edith Cowan University
S.M. Laws (Author/Creator) - Edith Cowan University
I.. Martins (Author/Creator) - Edith Cowan University
F.L. Mastaglia (Author/Creator) - The University of Western Australia
J.K. Foster (Author/Creator) - Edith Cowan University
J.K. Phillips (Author/Creator) - Murdoch University
R.N. Martins (Author/Creator) - Edith Cowan University
Publication Details: Neurobiology of Aging, Vol.33(6), pp.1054-1056
Publisher: Elsevier Inc
Identifiers: 991005542600007891
Copyright: Crown Copyright (C) 2012
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

60 Record Views

11 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Mechanisms
Web Of Science research areas: Geriatrics & Gerontology; Neurosciences
ESI research areas: Neuroscience & Behavior