Further studies of the effect of selection with levamisole on a benzimidazole resistant population of Ostertagia spp. of sheep

P.J. Waller; R.J. Dobson; A.D. Donald

doi:10.1016/S0020-7519(83)80009-5

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Further studies of the effect of selection with levamisole on a benzimidazole resistant population of Ostertagia spp. of sheep

Journal article

Peer reviewed

Further studies of the effect of selection with levamisole on a benzimidazole resistant population of Ostertagia spp. of sheep

P.J. Waller, R.J. Dobson and A.D. Donald

International Journal for Parasitology, Vol.13(5), pp.463-468

1983

DOI: https://doi.org/10.1016/S0020-7519(83)80009-5

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Abstract

Fresh isolations of Ostertagia spp. from sheep in a continuing field experiment confirmed a substantially lower level of benzimidazole resistance in the progeny of worms which had survived repeated doses of levamisole than in the progeny of those not exposed to any anthelmintic for 7 months. These resistance levels had remained unchanged for 4 months. Five generations of laboratory selection with levamisole had no effect on the level of benzimidazole resistance in a highly resistant line of the parasite isolated from the same field experiment. The effect of levamisole treatment in the field experiment was probably not due to a negative correlation between benzimidazole and levamisole resistance in the parasitic stages, but could be explained by the population dynamics of the parasite. It is postulated that levamisole treatment resulted in the replacement of a highly benzimidazole resistant parasitic population by one reflecting a lower frequency of resistant individuals in the infective larval population on pasture at the time of the first levamisole dose. Despite gradually increasing persistent faecal egg counts of Ostertagia spp. in the grazing sheep receiving 4-weekly doses of levamisole, the progeny of these worms, either as fourth stage larvae or as adults, were not resistant to levamisole.

Details

Title: Further studies of the effect of selection with levamisole on a benzimidazole resistant population of Ostertagia spp. of sheep
Authors/Creators: P.J. Waller (Author/Creator) - McMaster-Carr
R.J. Dobson (Author/Creator) - McMaster-Carr
A.D. Donald (Author/Creator) - McMaster-Carr
Publication Details: International Journal for Parasitology, Vol.13(5), pp.463-468
Publisher: Elsevier BV
Identifiers: 991005544601107891
Copyright: © 1983 Published by Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.1022 Anthelmintic Resistance
Web Of Science research areas: Parasitology
ESI research areas: Microbiology