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Published (Version of Record)CC BY V4.0, Open Access
Journal article
GS-2: A novel broad-spectrum agent for environmental microbial control
Biomolecules, Vol.12(9), Article 1293
2022
Abstract
The environmental control of microbial pathogens currently relies on compounds that do not exert long-lasting activity on surfaces, are impaired by soil, and contribute to the growing problem of antimicrobial resistance. This study presents the scientific development and characterization of GS-2, a novel, water-soluble ammonium carboxylate salt of capric acid and L-arginine that demonstrates activity against a range of bacteria (particularly Gram-negative bacteria), fungi, and viruses. In real-world surface testing, GS-2 was more effective than a benzalkonium chloride disinfectant at reducing the bacterial load on common touch-point surfaces in a high-traffic building (average 1.6 vs. 32.6 CFUs recovered from surfaces 90 min after application, respectively). Toxicology testing in rats confirmed GS-2 ingredients were rapidly cleared and posed no toxicities to humans or animals. To enhance the time-kill against Gram-positive bacteria, GS-2 was compounded at a specific ratio with a naturally occurring monoterpenoid, thymol, to produce a water-based antimicrobial solution. This GS-2 with thymol formulation could generate a bactericidal effect after five minutes of exposure and a viricidal effect after 10 min of exposure. Further testing of the GS-2 and thymol combination on glass slides demonstrated that the compound retained bactericidal activity for up to 60 days. Based on these results, GS-2 and GS-2 with thymol represent a novel antimicrobial solution that may have significant utility in the long-term reduction of environmental microbial pathogens in a variety of settings.
Details
- Title
- GS-2: A novel broad-spectrum agent for environmental microbial control
- Authors/Creators
- A.J. Mayfosh (Author/Creator) - ACTZ.I. Day (Author/Creator)N.B. Unsworth (Author/Creator)C-Q Liu (Author/Creator)R. Gupta (Author/Creator)S. Haynes (Author/Creator)R. Abraham (Author/Creator)S. Abraham (Author/Creator)Z.L. Shaw (Author/Creator)S. Walia (Author/Creator)A. Elbourne (Author/Creator)M.D. Hulett (Author/Creator)T.F. Rau (Author/Creator)
- Publication Details
- Biomolecules, Vol.12(9), Article 1293
- Publisher
- MDPI
- Identifiers
- 991005542294607891
- Copyright
- © 2022 by the authors
- Murdoch Affiliation
- Harry Butler Institute; Antimicrobial Resistance and Infectious Disease Laboratory
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Biology & Biochemistry