Journal article
Gait impairment precedes clinical symptoms in spinocerebellar ataxia type 6
Movement Disorders, Vol.29(2), pp.252-255
2013
Abstract
Background
Spinocerebellar ataxia type 6 (SCA6) is an inherited ataxia with no established treatment. Gait ataxia is a prominent feature causing substantial disability. Understanding the evolution of the gait disturbance is a key step in developing treatment strategies.
Methods
We studied 9 gait variables in 24 SCA6 (6 presymptomatic; 18 symptomatic) and 24 controls and correlated gait with clinical severity (presymptomatic and symptomatic).
Results
Discrete gait characteristics precede symptoms in SCA6 with significantly increased variability of step width and step time, whereas a more global gait deficit was evident in symptomatic individuals. Gait characteristics discriminated between presymptomatic and symptomatic individuals and were selectively associated with disease severity.
Conclusions
This is the largest study to include a detailed characterization of gait in SCA6, including presymptomatic subjects, allowing changes across the disease spectrum to be compared. Selective gait disturbance is already present in SCA6 before clinical symptoms appear and gait characteristics are also sensitive to disease progression. Early gait disturbance likely reflects primary pathology distinct from secondary changes. These findings open the opportunity for early evaluation and sensitive measures of therapeutic efficacy using instrumented gait analysis which may have broader relevance for all degenerative ataxias.
Details
- Title
- Gait impairment precedes clinical symptoms in spinocerebellar ataxia type 6
- Authors/Creators
- L. Rochester (Author/Creator) - Newcastle UniversityB. Galna (Author/Creator) - Newcastle UniversityS. Lord (Author/Creator) - Newcastle UniversityD. Mhiripiri (Author/Creator) - Newcastle UniversityG. Eglon (Author/Creator) - Newcastle UniversityP.F. Chinnery (Author/Creator) - Newcastle University
- Publication Details
- Movement Disorders, Vol.29(2), pp.252-255
- Publisher
- Wiley Online Library
- Identifiers
- 991005545996107891
- Copyright
- © 2013 International Parkinson and Movement Disorder Society
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.951 Huntington's and Ataxias
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior