Files and links (2)
Gait progression over 6 years in Parkinson’s disease - Effects of age, medication, and pathology.pdf
Published (Version of Record)CC BY V4.0, Open Access
Journal article
Gait progression over 6 years in Parkinson’s disease: Effects of age, medication, and pathology
Frontiers in Aging Neuroscience, Vol.12, Article 577435
2020
Abstract
Background: Gait disturbance is an early, cardinal feature of Parkinson’s disease (PD) associated with falls and reduced physical activity. Progression of gait impairment in Parkinson’s disease is not well characterized and a better understanding is imperative to mitigate impairment. Subtle gait impairments progress in early disease despite optimal dopaminergic medication. Evaluating gait disturbances over longer periods, accounting for typical aging and dopaminergic medication changes, will enable a better understanding of gait changes and inform targeted therapies for early disease. This study aimed to describe gait progression over the first 6 years of PD by delineating changes associated with aging, medication, and pathology.
Methods: One-hundred and nine newly diagnosed PD participants and 130 controls completed at least two gait assessments. Gait was assessed at 18-month intervals for up to 6 years using an instrumented walkway to measure sixteen spatiotemporal gait characteristics. Linear mixed-effects models assessed progression.
Results: Ten gait characteristics significantly progressed in PD, with changes in four of these characteristics attributable to disease progression. Age-related changes also contributed to gait progression; changes in another two characteristics reflected both aging and disease progression. Gait impairment progressed irrespective of dopaminergic medication change for all characteristics except step width variability.
Conclusions: Discrete gait impairments continue to progress in PD over 6 years, reflecting a combination of, and potential interaction between, disease-specific progression and age-related change. Gait changes were mostly unrelated to dopaminergic medication adjustments, highlighting limitations of current dopaminergic therapy and the need to improve interventions targeting gait decline.
Details
- Title
- Gait progression over 6 years in Parkinson’s disease: Effects of age, medication, and pathology
- Authors/Creators
- J. Wilson (Author/Creator)L. Alcock (Author/Creator)A.J. Yarnall (Author/Creator)S. Lord (Author/Creator)R.A. Lawson (Author/Creator)R. Morris (Author/Creator)J.-P. Taylor (Author/Creator)D.J. Burn (Author/Creator)L. Rochester (Author/Creator)B. Galna (Author/Creator)
- Publication Details
- Frontiers in Aging Neuroscience, Vol.12, Article 577435
- Publisher
- Frontiers Media
- Identifiers
- 991005541905807891
- Copyright
- © 2020 Wilson, Alcock, Yarnall, Lord, Lawson, Morris, Taylor, Burn, Rochester and Galna
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
95 File views/ downloads
55 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.263 Gait and Balance
- Web Of Science research areas
- Geriatrics & Gerontology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior