Gait rather than cognition predicts decline in specific cognitive domains in early Parkinson’s disease

R. Morris; S. Lord; R.A. Lawson; S. Coleman; B. Galna; G.W. Duncan; T.K. Khoo; A.J. Yarnall; D.J. Burn; L. Rochester

doi:10.1093/gerona/glx071

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Gait rather than cognition predicts decline in specific cognitive domains in early Parkinson’s disease

Journal article

Open access

Peer reviewed

Gait rather than cognition predicts decline in specific cognitive domains in early Parkinson’s disease

R. Morris, S. Lord, R.A. Lawson, S. Coleman, B. Galna, G.W. Duncan, T.K. Khoo, A.J. Yarnall, D.J. Burn and L. Rochester

The Journals of Gerontology: Series A, Vol.72(12), pp.1656-1662

2017

DOI: https://doi.org/10.1093/gerona/glx071

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Abstract

Background Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD. Methods One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline. Results Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline. Conclusions This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.

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Title: Gait rather than cognition predicts decline in specific cognitive domains in early Parkinson’s disease
Authors/Creators: R. Morris (Author/Creator) - Institute of Neuroscience
S. Lord (Author/Creator) - Institute of Neurosciences Kolkata
R.A. Lawson (Author/Creator) - Institute of Neurosciences Kolkata
S. Coleman (Author/Creator) - UK and Industrial Statistics Research Unit.
B. Galna (Author/Creator) - Newcastle University
G.W. Duncan (Author/Creator) - University of Edinburgh
T.K. Khoo (Author/Creator) - Griffith University
A.J. Yarnall (Author/Creator) - Institute of Neurosciences Kolkata
D.J. Burn (Author/Creator) - Institute of Neurosciences Kolkata
L. Rochester (Author/Creator) - Institute of Neurosciences Kolkata
Publication Details: The Journals of Gerontology: Series A, Vol.72(12), pp.1656-1662
Publisher: Oxford University Press on behalf of The Gerontological Society of America
Identifiers: 991005543043507891
Copyright: © The Author 2017
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.82 Gait & Posture; 1.82.263 Gait and Balance
Web Of Science research areas: Geriatrics & Gerontology; Gerontology
ESI research areas: Clinical Medicine