Journal article
Galactocerebroside antiserum causes demyelination of cat optic nerve
Brain Research, Vol.330(2), pp.378-381
1985
Abstract
A model of immune-mediated optic nerve demyelination is described. Micro-injection of small volumes (< 5 μl) of high titer polyclonal anti-Gal-C serum into the cat optic nerve resulted in a focal, highly selective demyelinative lesion followed by remyelination. Demyelination appears to be due to a dual effect of myelin and on oligadendrocytes. The numbers of these cels within the lesion were initially reduced but subsequently increased as remyelination occured.
Details
- Title
- Galactocerebroside antiserum causes demyelination of cat optic nerve
- Authors/Creators
- W.M. Carroll (Author/Creator) - Queen Elizabeth II Medical CentreA.R. Jennings (Author/Creator) - Queen Elizabeth II Medical CentreF.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
- Publication Details
- Brain Research, Vol.330(2), pp.378-381
- Publisher
- Elsevier BV
- Identifiers
- 991005543070807891
- Copyright
- © 1985 Published by Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.1430 Oligodendrocyte Myelination
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior