Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice

J.C. Lenzo; G.R. Shellam; C.M. Lawson

doi:10.1128/AAC.45.5.1444-1449.2001

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Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice

Journal article

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Peer reviewed

Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice

J.C. Lenzo, G.R. Shellam and C.M. Lawson

Antimicrobial agents and chemotherapy, Vol.45(5), pp.1444-1449

2001

DOI: https://doi.org/10.1128/AAC.45.5.1444-1449.2001

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Abstract

The cardiovascular disease myocarditis is characterized by inflammation and necrosis of cardiac muscle. This disease has been associated with various viral etiologies, including cytomegalovirus (CMV). Murine CMV (MCMV) infection of adult BALB/c mice produces a disease with acute and chronic phases similar to that found in humans. In our murine model, we have investigated the therapeutic efficacy of antiviral drug administration on myocarditis. Two drugs commonly used for CMV treatment, ganciclovir and cidofovir, were subjected to trials, with both drugs showing potent antiviral activity against MCMV both in vitro and in vivo. The acute phase of myocarditis was significantly reduced when antiviral therapy commenced 24 h postinfection. Such treatment also reduced the severity of the chronic phase of myocarditis. In contrast, antiviral treatment commencing after the acute phase had no effect on chronic myocarditis. Reinfection of mice with MCMV caused exacerbation of myocardial inflammation. Such an increase in severity of myocarditis could be prevented with either ganciclovir or cidofovir treatment, but the preexisting inflammation and necrosis of the myocardium persisted. These data highlight possible therapeutic uses of antiviral drugs in viral myocarditis as well as further elucidating the pathogenic nature of the disease.

Details

Title: Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice
Authors/Creators: J.C. Lenzo (Author/Creator) - The University of Western Australia
G.R. Shellam (Author/Creator) - The University of Western Australia
C.M. Lawson (Author/Creator) - Murdoch University
Publication Details: Antimicrobial agents and chemotherapy, Vol.45(5), pp.1444-1449
Publisher: American Society for Microbiology
Identifiers: 991005540200907891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.37 Cardiology - General; 1.37.1920 Myocarditis
Web Of Science research areas: Microbiology; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology