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Garlic bioactive substances and their therapeutic applications for improving human health: a comprehensive review
Journal article   Open access   Peer reviewed

Garlic bioactive substances and their therapeutic applications for improving human health: a comprehensive review

Mohamed T. El-Saadony, Ahmed M. Saad, Sameh A. Korma, Heba M. Salem, Taia A. Abd El-Mageed, Samar Sami Alkafaas, Mohamed I. Elsalahaty, Sara Samy Elkafas, Walid F. A. Mosa, Ahmed Ezzat Ahmed, …
Frontiers in immunology, Vol.15, 1277074
2024
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Published (Version of Record)CC BY V4.0 Open Access

Abstract

Allium sativum bioactive compounds functional foods human diseases human health mechanisms of action toxicity
Garlic ( Allium sativum L.) is a widely abundant spice, known for its aroma and pungent flavor. It contains several bioactive compounds and offers a wide range of health benefits to humans, including those pertaining to nutrition, physiology, and medicine. Therefore, garlic is considered as one of the most effective disease-preventive diets. Many in vitro and in vivo studies have reported the sulfur-containing compounds, allicin and ajoene, for their effective anticancer, anti-diabetic, anti-inflammatory, antioxidant, antimicrobial, immune-boosting, and cardioprotective properties. As a rich natural source of bioactive compounds, including polysaccharides, saponins, tannins, linalool, geraniol, phellandrene, β-phellandrene, ajoene, alliin, S-allyl-mercapto cysteine, and β-phellandrene, garlic has many therapeutic applications and may play a role in drug development against various human diseases. In the current review, garlic and its major bioactive components along with their biological function and mechanisms of action for their role in disease prevention and therapy are discussed.

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UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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