Journal article
Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver diseas
Hepatology, Vol.53(3), pp.800-809
2011
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a predominantly adult-diagnosed disorder. Knowledge regarding the epidemiology, phenotype, and metabolic risk factors, during adolescence is limited. We sought to determine the prevalence, phenotype, and predictors of NAFLD in 1170 community-based adolescents in the Western Australian Pregnancy Cohort (Raine) Study (the Raine Cohort) who underwent a cross-sectional assessment that included questionnaires, anthropometry, cardiovascular examinations, blood tests, and abdominal ultrasound examinations. Among the 1170 adolescents assessed, the prevalence of NAFLD was 12.8%. Females compared with males had a significantly higher prevalence of NAFLD (16.3% versus 10.1%, P = 0.004) and central obesity (33.2% versus 9.9%, P < 0.05). The severity of hepatic steatosis was associated with the body mass index, waist circumference, subcutaneous adipose tissue thickness (SAT), serum leptin level, homeostasis model assessment for insulin resistance score (P < 0.001 for all), and serum alanine aminotransferase level (P < 0.005) in both genders, but it was associated with increasing visceral adipose tissue thickness (VAT; P < 0.001) and decreasing serum adiponectin levels (P < 0.05) in males alone. Males and females with NAFLD had similar amounts of SAT (P > 0.05); however, in comparison with females with NAFLD, males with NAFLD had greater VAT, a more severe metabolic phenotype with higher glucose levels and systolic blood pressure and lower adiponectin and high-density lipoprotein cholesterol levels (P < 0.001 for all), and greater measures of liver injury (alanine aminotransferase and aspartate aminotransferase, P < 0.001 for all). Similarly, metabolic syndrome was more common in males than females with NAFLD (24% versus 8%, P = 0.01). Suprailiac skinfold thickness predicted NAFLD independently of the body mass index, insulin resistance, and VAT. Conclusion: Gender differences in adolescent NAFLD are related to differences in adipose distribution and adipocytokines. The male phenotype of NAFLD is associated with more adverse metabolic features and greater visceral adiposity than the female phenotype despite the lower prevalence of NAFLD.
Details
- Title
- Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver diseas
- Authors/Creators
- O.T. Ayonrinde (Author/Creator) - The University of Western AustraliaJ.K. Olynyk (Author/Creator) - The University of Western AustraliaL.J. Beilin (Author/Creator) - The University of Western AustraliaT.A. Mori (Author/Creator) - The University of Western AustraliaC.E. Pennell (Author/Creator) - The University of Western AustraliaN. De Klerk (Author/Creator) - The Kids Research Institute AustraliaW.H. Oddy (Author/Creator) - The Kids Research Institute AustraliaP. Shipman (Author/Creator) - Princess Margaret Hospital for ChildrenL.A. Adams (Author/Creator) - Sir Charles Gairdner Hospital
- Publication Details
- Hepatology, Vol.53(3), pp.800-809
- Publisher
- John Wiley & Sons Inc.
- Identifiers
- 991005542143307891
- Copyright
- © 2010 American Association for the Study of Liver Diseases
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.663 NAFLD
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine