Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses

G. Baynam; G. Zhang; S-K Khoo; P. Sly; P. Holt; J. Goldblatt; P.N. Le Souëf

doi:10.1016/j.vaccine.2008.05.011

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Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses

Journal article

Peer reviewed

Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses

G. Baynam, G. Zhang, S-K Khoo, P. Sly, P. Holt, J. Goldblatt and P.N. Le Souëf

Vaccine, Vol.26(29-30), pp.3574-3579

2008

DOI: https://doi.org/10.1016/j.vaccine.2008.05.011

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Abstract

Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Rα I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p = 0.01, TetTox p = 0.04; IL-4Rα.I50V: DipTox p = 0.04, TetTox p = 0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p = 0.03) and TetTox (p = 0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p = 0.01) and IL-4Rα I50V (p = 0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses.

Details

Title: Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses
Authors/Creators: G. Baynam (Author/Creator)
G. Zhang (Author/Creator)
S-K Khoo (Author/Creator)
P. Sly (Author/Creator)
P. Holt (Author/Creator)
J. Goldblatt (Author/Creator)
P.N. Le Souëf (Author/Creator)
Publication Details: Vaccine, Vol.26(29-30), pp.3574-3579
Publisher: Elsevier BV
Identifiers: 991005542008907891
Copyright: © 2008 Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.44 Asthma
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology