Journal article
Gene expression analysis of the corticotrophin-releasing Hormone-proopiomelanocortin system in psoriasis skin biopsies
Acta Dermato Venereologica, Vol.93(4), pp.400-405
2013
Abstract
The corticotrophin-releasing hormone-proopiomelano-cortin (CRH-POMC) system in the skin coordinates pigmentation and the immune response. The aim of this study was to evaluate the regulatory role of the neuroendocrine system in the pathogenesis of psoriasis. Using quantitative real-time-PCR, mRNA expression levels of 15 genes related to the CRH-POMC system were measured in punch biopsies from lesional and non-lesional skin of patients with psoriasis and from skin of healthy control subjects. Statistically significant up-regulation of POMC, CRH receptor type 1, melanin-concentrating hormone receptor (MCHR1) and melanocortin receptors 2, 3 and 4 mRNA expression in lesional and in non-lesional skin compared with healthy control samples were established. Tyrosinase (TYR), T(Y)RP-1 and ASIP genes were statistically significantly down-regulated in lesional and non-lesional skin of psoriasis samples compared with healthy subjects. The up-regulation of POMC, melanocortin receptors, CRH receptor type 1 and MCHR1 in the lesional and non-lesional skin of psoriasis patients supports the importance of the local CRH-POMC system in the pathogenesis of psoriasis.
Details
- Title
- Gene expression analysis of the corticotrophin-releasing Hormone-proopiomelanocortin system in psoriasis skin biopsies
- Authors/Creators
- U. Loite (Author/Creator) - University of TartuK. Kingo (Author/Creator)E. Reimann (Author/Creator)P. Reemann (Author/Creator)E. Vasar (Author/Creator)H. Silm (Author/Creator)S. Kõks (Author/Creator)
- Publication Details
- Acta Dermato Venereologica, Vol.93(4), pp.400-405
- Publisher
- Acta Dermato-Venereologica
- Identifiers
- 991005544827907891
- Copyright
- © 2013 Acta Dermato-Venereologica
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.737 Psoriasis
- Web Of Science research areas
- Dermatology
- ESI research areas
- Clinical Medicine