Gene therapy: Therapeutic applications and relevance to pathology

G. Both; I. Alexander; S. Fletcher; T.J. Nicolson; J.E.J. Rasko; S.D. Wilton; G. Symonds

doi:10.1097/PAT.0b013e32834b1dad

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Gene therapy: Therapeutic applications and relevance to pathology

Journal article

Peer reviewed

Gene therapy: Therapeutic applications and relevance to pathology

G. Both, I. Alexander, S. Fletcher, T.J. Nicolson, J.E.J. Rasko, S.D. Wilton and G. Symonds

Pathology, Vol.43(6), pp.642-656

2011

DOI: https://doi.org/10.1097/PAT.0b013e32834b1dad

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Abstract

Summary: This review discusses gene therapy as a new treatment paradigm where genetic material is introduced into cells for therapeutic benefit. The genetic material is the ‘drug’. It can have a transient or ongoing effect depending on whether or not the introduced genetic material becomes part of the host cell DNA. Different delivery and gene technologies are chosen by investigators to maximise gene delivery to, and expression within, the target cells appropriate for the disease indication. The presence and expression of the introduced genetic material is monitored by molecular means so that treatment efficacy can be assessed via changes in surrogate and/or actual markers of disease. Of interest to the pathologist will be the approaches being developed for the disease indications highlighted and the monitoring of treatment efficacy.

Details

Title: Gene therapy: Therapeutic applications and relevance to pathology
Authors/Creators: G. Both (Author/Creator)
I. Alexander (Author/Creator)
S. Fletcher (Author/Creator)
T.J. Nicolson (Author/Creator)
J.E.J. Rasko (Author/Creator)
S.D. Wilton (Author/Creator)
G. Symonds (Author/Creator)
Publication Details: Pathology, Vol.43(6), pp.642-656
Publisher: Taylor & Francis
Identifiers: 991005541711907891
Copyright: © 2011 Royal College of Pathologists of Australasia
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.161 Virology - Identification & Sequencing; 1.161.479 Oncolytic Viruses
Web Of Science research areas: Pathology
ESI research areas: Clinical Medicine