Genetic architecture of subcortical brain structures in 38,851 individuals

C.L. Satizabal; H.H.H. Adams; D.P. Hibar; C.C. White; M.J. Knol; J.L. Stein; M. Scholz; M. Sargurupremraj; N. Jahanshad; G.V. Roshchupkin; A.V. Smith; J.C. Bis; X. Jian; M. Luciano; E. Hofer; A. Teumer; S.J. van der Lee; J. Yang; L.R. Yanek; T.V. Lee; S. Li; Y. Hu; J.Y. Koh; J.D. Eicher; S. Desrivières; A. Arias-Vasquez; G. Chauhan; L. Athanasiu; M.E. Renteria; S. Kim; D. Hoehn; N.J. Armstrong; Q. Chen; A.J. Holmes; A. den Braber; I. Kloszewska; M. Andersson; T. Espeseth; O. Grimm; L. Abramovic; S. Alhusaini; Y. Milaneschi; M. Papmeyer; T. Axelsson; S. Ehrlich; R. Roiz-Santiañez; B. Kraemer; A.K. Håberg; H.J. Jones; G.B. Pike; D.J. Stein; A. Stevens; J. Bralten; M.W. Vernooij; T.B. Harris; I. Filippi; A.V. Witte; T. Guadalupe; K. Wittfeld; T.H. Mosley; J.T. Becker; N.T. Doan; S.P. Hagenaars; Y. Saba; G. Cuellar-Partida; N. Amin; S. Hilal; K. Nho; N. Mirza-Schreiber; K. Arfanakis; D.M. Becker; D. Ames; A.L. Goldman; P.H. Lee; D.I. Boomsma; S. Lovestone; S. Giddaluru; S. Le Hellard; M. Mattheisen; M.M. Bohlken; D. Kasperaviciute; L. Schmaal; S.M. Lawrie; I. Agartz; E. Walton; D. Tordesillas-Gutierrez; G.E. Davies; J. Shin; J.C. Ipser; L.N. Vinke; M. Hoogman; T. Jia; R. Burkhardt; M. Klein; F. Crivello; D. Janowitz; O. Carmichael; U.K. Haukvik; B.S. Aribisala; H. Schmidt; L.T. Strike; C-Y Cheng; S.L. Risacher; B. Pütz; D.A. Fleischman; A.A. Assareh; V.S. Mattay; R.L. Buckner; P. Mecocci; A.M. Dale; S. Cichon; M.P. Boks; M. Matarin; B.W.J.H. Penninx; V.D. Calhoun; M.M. Chakravarty; A.F. Marquand; C. Macare; S. Kharabian Masouleh; J. Oosterlaan; P. Amouyel; K. Hegenscheid; J.I. Rotter; A.J. Schork; D.C.M. Liewald; G.I. de Zubicaray; T.Y. Wong; L. Shen; P.G. Sämann; H. Brodaty; J.L. Roffman; E.J.C. de Geus; M. Tsolaki; S. Erk; K.R. van Eijk; G.L. Cavalleri; N.J.A. van der Wee; A.M. McIntosh; R.L. Gollub; K.B. Bulayeva; M. Bernard; J.S. Richards; J.J. Himali; M. Loeffler; N. Rommelse; W. Hoffmann; L.T. Westlye; M.C. Valdés Hernández; N.K. Hansell; T.G.M. Van Erp; C. Wolf; J.B.J. Kwok; B. Vellas; A. Heinz; L.M. Olde Loohuis; N. Delanty; B-C. Ho; C.R.K. Ching; E. Shumskaya; B. Singh; A. Hofman; D. van der Meer; G. Homuth; B.M. Psaty; M.E. Bastin; G.W. Montgomery; T.M. Foroud; S. Reppermund; J-J Hottenga; A. Simmons; A. Meyer-Lindenberg; W. Cahn; C.D. Whelan; M.M.J. van Donkelaar; Q. Yang; N. Hosten; R.C. Green; A. Thalamuthu; S. Mohnke; H.E. Hulshoff Pol; H. Lin; C.R. Jack; P.R. Schofield; T.W. Mühleisen; P. Maillard; S.G. Potkin; W. Wen; E. Fletcher; A.W. Toga; O. Gruber; M. Huentelman; G. Davey Smith; L.J. Launer; L. Nyberg; E.G. Jönsson; B. Crespo-Facorro; N. Koen; D.N. Greve; A.G. Uitterlinden; D.R. Weinberger; V.M. Steen; I.O. Fedko; N.A. Groenewold; W.J. Niessen; R. Toro; C. Tzourio; W.T. Longstreth; M.K. Ikram; J.W. Smoller; M-J van Tol; J.E. Sussmann; T. Paus; H. Lemaitre; M.L. Schroeter; B. Mazoyer; O.A. Andreassen; F. Holsboer; C. Depondt; D.J. Veltman; J.A. Turner; Z. Pausova; G. Schumann; D. Van Rooij; S. Djurovic; I.J. Deary; K.L. McMahon; B. Müller-Myhsok; R.M. Brouwer; H. Soininen; M. Pandolfo; T.H. Wassink; J.W. Cheung; T. Wolfers; J-L Martinot; M.P. Zwiers; M. Nauck; I. Melle; N.G. Martin; R. Kanai; E. Westman; R.S. Kahn; S.M. Sisodiya; T. White; A. Saremi; H. van Bokhoven; H.G. Brunner; H. Völzke; M.J. Wright; D. van ‘t Ent; M.M. Nöthen; R.A. Ophoff; J.K. Buitelaar; G. Fernández; P.S. Sachdev; M. Rietschel; N.E.M. van Haren; S.E. Fisher; A.S. Beiser; C. Francks; A.J. Saykin; K.A. Mather; N. Romanczuk-Seiferth; C.A. Hartman; A.L. DeStefano; D.J. Heslenfeld; M.W. Weiner; H. Walter; P.J. Hoekstra; P.A. Nyquist; B. Franke; D.A. Bennett; H.J. Grabe; A.D. Johnson; C. Chen; C.M. van Duijn; O.L. Lopez; M. Fornage; J.M. Wardlaw; R. Schmidt; C. DeCarli; P.L. De Jager; A. Villringer; S. Debette; V. Gudnason; S.E. Medland; J.M. Shulman; P.M. Thompson; S. Seshadri; M.A. Ikram

doi:10.1038/s41588-019-0511-y

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Genetic architecture of subcortical brain structures in 38,851 individuals

Journal article

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Genetic architecture of subcortical brain structures in 38,851 individuals

C.L. Satizabal, H.H.H. Adams, D.P. Hibar, C.C. White, M.J. Knol, J.L. Stein, M. Scholz, M. Sargurupremraj, N. Jahanshad, G.V. Roshchupkin, …

Nature Genetics, Vol.51(11), pp.1624-1636

2019

DOI: https://doi.org/10.1038/s41588-019-0511-y

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Abstract

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Details

Title: Genetic architecture of subcortical brain structures in 38,851 individuals
Authors/Creators: C.L. Satizabal (Author/Creator) - Boston University
H.H.H. Adams (Author/Creator) - Erasmus University Rotterdam
D.P. Hibar (Author/Creator) - University of Southern California
C.C. White (Author/Creator) - Columbia University
M.J. Knol (Author/Creator) - Erasmus University Rotterdam
J.L. Stein (Author/Creator)
M. Scholz (Author/Creator) - Leipzig University
M. Sargurupremraj (Author/Creator) - Université de Bordeaux
N. Jahanshad (Author/Creator) - University of Southern California
G.V. Roshchupkin (Author/Creator) - Erasmus University Rotterdam
A.V. Smith (Author/Creator) - University of Michigan
J.C. Bis (Author/Creator) - University of Washington
X. Jian (Author/Creator) - The University of Texas Health Science Center at Houston
M. Luciano (Author/Creator) - University of Edinburgh
E. Hofer (Author/Creator) - Medical University of Graz
A. Teumer (Author/Creator) - Universitätsmedizin Greifswald
S.J. van der Lee (Author/Creator) - Erasmus University Rotterdam
J. Yang (Author/Creator) - Rush University Medical Center
L.R. Yanek (Author/Creator) - Johns Hopkins Medicine
T.V. Lee (Author/Creator) - Baylor College of Medicine
S. Li (Author/Creator) - Boston University
Y. Hu (Author/Creator) - Harvard University
J.Y. Koh (Author/Creator) - Singapore National Eye Center
J.D. Eicher (Author/Creator)
S. Desrivières (Author/Creator) - King's College London
A. Arias-Vasquez (Author/Creator) - Radboud University Nijmegen
G. Chauhan (Author/Creator) - Université de Bordeaux
L. Athanasiu (Author/Creator) - University of Oslo
M.E. Renteria (Author/Creator) - QIMR Berghofer Medical Research Institute
S. Kim (Author/Creator) - Indiana University
D. Hoehn (Author/Creator) - Max Planck Society
N.J. Armstrong (Author/Creator) - Murdoch University
Q. Chen (Author/Creator)
A.J. Holmes (Author/Creator) - Yale University
A. den Braber (Author/Creator)
I. Kloszewska (Author/Creator)
M. Andersson (Author/Creator) - Umeå University
T. Espeseth (Author/Creator) - University of Oslo
O. Grimm (Author/Creator) - Heidelberg University
L. Abramovic (Author/Creator) - Utrecht University
S. Alhusaini (Author/Creator) - Yale University
Y. Milaneschi (Author/Creator) - Vrije Universiteit Amsterdam
M. Papmeyer (Author/Creator) - University of Edinburgh
T. Axelsson (Author/Creator) - Uppsala University
S. Ehrlich (Author/Creator) - Technische Universität Dresden
R. Roiz-Santiañez (Author/Creator) - Universidad de Cantabria
B. Kraemer (Author/Creator) - Heidelberg University
A.K. Håberg (Author/Creator) - Norwegian University of Science and Technology
H.J. Jones (Author/Creator) - University of Bristol
G.B. Pike (Author/Creator) - University of Calgary
D.J. Stein (Author/Creator) - University of Southern California
A. Stevens (Author/Creator) - Harvard University
J. Bralten (Author/Creator) - Radboud University Nijmegen
M.W. Vernooij (Author/Creator) - Erasmus University Rotterdam
T.B. Harris (Author/Creator) - National Institutes of Health
I. Filippi (Author/Creator) - Délégation Paris 5
A.V. Witte (Author/Creator) - Max Planck Society
T. Guadalupe (Author/Creator) - Max Planck Society
K. Wittfeld (Author/Creator) - Universitätsmedizin Greifswald
T.H. Mosley (Author/Creator) - University of Mississippi
J.T. Becker (Author/Creator) - University of Pittsburgh
N.T. Doan (Author/Creator) - University of Oslo
S.P. Hagenaars (Author/Creator) - University of Edinburgh
Y. Saba (Author/Creator) - Medical University of Graz
G. Cuellar-Partida (Author/Creator) - QIMR Berghofer Medical Research Institute
N. Amin (Author/Creator) - Erasmus University Rotterdam
S. Hilal (Author/Creator) - National University of Singapore
K. Nho (Author/Creator) - Indiana University
N. Mirza-Schreiber (Author/Creator) - Max Planck Society
K. Arfanakis (Author/Creator) - Illinois Institute of Technology
D.M. Becker (Author/Creator) - Johns Hopkins Medicine
D. Ames (Author/Creator) - The University of Melbourne
A.L. Goldman (Author/Creator)
P.H. Lee (Author/Creator) - Broad Institute
D.I. Boomsma (Author/Creator) - Vrije Universiteit Amsterdam
S. Lovestone (Author/Creator) - University of Oxford
S. Giddaluru (Author/Creator) - University of Bergen
S. Le Hellard (Author/Creator) - University of Bergen
M. Mattheisen (Author/Creator)
M.M. Bohlken (Author/Creator) - Utrecht University
D. Kasperaviciute (Author/Creator) - University College London
L. Schmaal (Author/Creator) - The University of Melbourne
S.M. Lawrie (Author/Creator) - University of Edinburgh
I. Agartz (Author/Creator) - Karolinska Institutet
E. Walton (Author/Creator) - University of Bath
D. Tordesillas-Gutierrez (Author/Creator)
G.E. Davies (Author/Creator) - Avera Health
J. Shin (Author/Creator) - University of Toronto
J.C. Ipser (Author/Creator) - University of Cape Town
L.N. Vinke (Author/Creator) - Boston University
M. Hoogman (Author/Creator) - Radboud University Nijmegen
T. Jia (Author/Creator) - King's College London
R. Burkhardt (Author/Creator) - Leipzig University
M. Klein (Author/Creator) - Radboud University Nijmegen
F. Crivello (Author/Creator) - Université de Bordeaux
D. Janowitz (Author/Creator) - Universitätsmedizin Greifswald
O. Carmichael (Author/Creator) - Pennington Biomedical Research Center
U.K. Haukvik (Author/Creator) - University of Oslo
B.S. Aribisala (Author/Creator) - University of Edinburgh
H. Schmidt (Author/Creator) - Medical University of Graz
L.T. Strike (Author/Creator) - The University of Queensland
C-Y Cheng (Author/Creator) - National University of Singapore
S.L. Risacher (Author/Creator) - Indiana University
B. Pütz (Author/Creator) - Max Planck Society
D.A. Fleischman (Author/Creator) - Rush University Medical Center
A.A. Assareh (Author/Creator) - UNSW Sydney
V.S. Mattay (Author/Creator) - Johns Hopkins University
R.L. Buckner (Author/Creator) - Harvard University
P. Mecocci (Author/Creator) - University of Perugia
A.M. Dale (Author/Creator) - University of California San Diego
S. Cichon (Author/Creator) - University of Basel
M.P. Boks (Author/Creator) - Utrecht University
M. Matarin (Author/Creator) - University College London
B.W.J.H. Penninx (Author/Creator) - Vrije Universiteit Amsterdam
V.D. Calhoun (Author/Creator) - University of New Mexico
M.M. Chakravarty (Author/Creator) - McGill University
A.F. Marquand (Author/Creator) - Radboud University Nijmegen
C. Macare (Author/Creator) - King's College London
S. Kharabian Masouleh (Author/Creator)
J. Oosterlaan (Author/Creator) - Vrije Universiteit Amsterdam
P. Amouyel (Author/Creator) - Lille University of Science and Technology
K. Hegenscheid (Author/Creator) - Universitätsmedizin Greifswald
J.I. Rotter (Author/Creator) - University of California, Los Angeles
A.J. Schork (Author/Creator) - Translational Genomics Research Institute
D.C.M. Liewald (Author/Creator) - University of Edinburgh
G.I. de Zubicaray (Author/Creator) - Queensland University of Technology
T.Y. Wong (Author/Creator) - National University of Singapore
L. Shen (Author/Creator) - University of Pennsylvania
P.G. Sämann (Author/Creator) - Max Planck Society
H. Brodaty (Author/Creator) - UNSW Sydney
J.L. Roffman (Author/Creator) - Harvard University
E.J.C. de Geus (Author/Creator) - Vrije Universiteit Amsterdam
M. Tsolaki (Author/Creator) - Aristotle University of Thessaloniki
S. Erk (Author/Creator) - Humboldt-Universität zu Berlin
K.R. van Eijk (Author/Creator)
G.L. Cavalleri (Author/Creator) - Royal College of Surgeons in Ireland
N.J.A. van der Wee (Author/Creator) - Leiden University
A.M. McIntosh (Author/Creator) - University of Edinburgh
R.L. Gollub (Author/Creator) - Harvard University
K.B. Bulayeva (Author/Creator)
M. Bernard (Author/Creator) - University of Toronto
J.S. Richards (Author/Creator) - Radboud University Nijmegen
J.J. Himali (Author/Creator) - Boston University
M. Loeffler (Author/Creator) - Leipzig University
N. Rommelse (Author/Creator) - Radboud University Nijmegen
W. Hoffmann (Author/Creator) - Universitätsmedizin Greifswald
L.T. Westlye (Author/Creator) - University of Oslo
M.C. Valdés Hernández (Author/Creator)
N.K. Hansell (Author/Creator) - The University of Queensland
T.G.M. Van Erp (Author/Creator) - University of California, Irvine
C. Wolf (Author/Creator) - University of Würzburg
J.B.J. Kwok (Author/Creator) - UNSW Sydney
B. Vellas (Author/Creator) - Université Fédérale de Toulouse Midi-Pyrénées
A. Heinz (Author/Creator) - Charité - Universitätsmedizin Berlin
L.M. Olde Loohuis (Author/Creator)
N. Delanty (Author/Creator) - Royal College of Surgeons in Ireland
B-C. Ho (Author/Creator) - University of Iowa
C.R.K. Ching (Author/Creator) - University of Southern California
E. Shumskaya (Author/Creator) - Radboud University Nijmegen
B. Singh (Author/Creator) - University of California, Davis
A. Hofman (Author/Creator) - Harvard University
D. van der Meer (Author/Creator) - Maastricht University
G. Homuth (Author/Creator) - Universitätsmedizin Greifswald
B.M. Psaty (Author/Creator) - University of Washington
M.E. Bastin (Author/Creator) - University of Edinburgh
G.W. Montgomery (Author/Creator) - The University of Queensland
T.M. Foroud (Author/Creator) - Indiana University
S. Reppermund (Author/Creator) - UNSW Sydney
J-J Hottenga (Author/Creator) - Vrije Universiteit Amsterdam
A. Simmons (Author/Creator) - Karolinska Institutet
A. Meyer-Lindenberg (Author/Creator) - Heidelberg University
W. Cahn (Author/Creator) - Utrecht University
C.D. Whelan (Author/Creator) - University of Southern California
M.M.J. van Donkelaar (Author/Creator) - Radboud University Nijmegen
Q. Yang (Author/Creator) - Boston University
N. Hosten (Author/Creator) - Universitätsmedizin Greifswald
R.C. Green (Author/Creator) - Harvard University
A. Thalamuthu (Author/Creator) - UNSW Sydney
S. Mohnke (Author/Creator) - Humboldt-Universität zu Berlin
H.E. Hulshoff Pol (Author/Creator)
H. Lin (Author/Creator) - Boston University
C.R. Jack (Author/Creator) - Mayo Clinic
P.R. Schofield (Author/Creator) - UNSW Sydney
T.W. Mühleisen (Author/Creator) - University of Basel
P. Maillard (Author/Creator) - University of California, Davis
S.G. Potkin (Author/Creator) - University of California, Irvine
W. Wen (Author/Creator) - UNSW Sydney
E. Fletcher (Author/Creator) - University of California, Davis
A.W. Toga (Author/Creator) - University of Southern California
O. Gruber (Author/Creator) - Heidelberg University
M. Huentelman (Author/Creator) - Translational Genomics Research Institute
G. Davey Smith (Author/Creator)
L.J. Launer (Author/Creator) - National Institutes of Health
L. Nyberg (Author/Creator) - Umeå University
E.G. Jönsson (Author/Creator) - Karolinska Institutet
B. Crespo-Facorro (Author/Creator) - Universidad de Cantabria
N. Koen (Author/Creator) - South African Medical Research Council
D.N. Greve (Author/Creator) - Harvard University
A.G. Uitterlinden (Author/Creator) - Erasmus University Rotterdam
D.R. Weinberger (Author/Creator) - Johns Hopkins University
V.M. Steen (Author/Creator) - University of Bergen
I.O. Fedko (Author/Creator) - Vrije Universiteit Amsterdam
N.A. Groenewold (Author/Creator) - University of Cape Town
W.J. Niessen (Author/Creator) - Delft University of Technology
R. Toro (Author/Creator) - Institut Pasteur
C. Tzourio (Author/Creator)
W.T. Longstreth (Author/Creator) - University of Washington
M.K. Ikram (Author/Creator)
J.W. Smoller (Author/Creator) - Broad Institute
M-J van Tol (Author/Creator) - University Medical Center Groningen
J.E. Sussmann (Author/Creator) - University of Edinburgh
T. Paus (Author/Creator) - University of Toronto
H. Lemaitre (Author/Creator) - Délégation Paris 5
M.L. Schroeter (Author/Creator) - Max Planck Society
B. Mazoyer (Author/Creator) - Université de Bordeaux
O.A. Andreassen (Author/Creator) - University of Oslo
F. Holsboer (Author/Creator) - Max Planck Society
C. Depondt (Author/Creator) - Université Libre de Bruxelles
D.J. Veltman (Author/Creator) - Vrije Universiteit Amsterdam
J.A. Turner (Author/Creator)
Z. Pausova (Author/Creator) - University of Toronto
G. Schumann (Author/Creator) - King's College London
D. Van Rooij (Author/Creator) - Radboud University Nijmegen
S. Djurovic (Author/Creator) - University of Bergen
I.J. Deary (Author/Creator) - University of Edinburgh
K.L. McMahon (Author/Creator) - Queensland University of Technology
B. Müller-Myhsok (Author/Creator) - University of Liverpool
R.M. Brouwer (Author/Creator) - Utrecht University
H. Soininen (Author/Creator) - University of Eastern Finland
M. Pandolfo (Author/Creator) - Université Libre de Bruxelles
T.H. Wassink (Author/Creator) - University of Iowa
J.W. Cheung (Author/Creator) - University of Southern California
T. Wolfers (Author/Creator) - Radboud University Nijmegen
J-L Martinot (Author/Creator) - Délégation Paris 5
M.P. Zwiers (Author/Creator) - Radboud University Nijmegen
M. Nauck (Author/Creator) - Universitätsmedizin Greifswald
I. Melle (Author/Creator) - University of Oslo
N.G. Martin (Author/Creator) - QIMR Berghofer Medical Research Institute
R. Kanai (Author/Creator) - University College London
E. Westman (Author/Creator) - Karolinska Institutet
R.S. Kahn (Author/Creator) - Icahn School of Medicine at Mount Sinai
S.M. Sisodiya (Author/Creator) - University College London
T. White (Author/Creator) - Erasmus University Rotterdam
A. Saremi (Author/Creator) - University of Southern California
H. van Bokhoven (Author/Creator) - Radboud University Nijmegen
H.G. Brunner (Author/Creator) - Maastricht University
H. Völzke (Author/Creator) - Universitätsmedizin Greifswald
M.J. Wright (Author/Creator) - The University of Queensland
D. van ‘t Ent (Author/Creator)
M.M. Nöthen (Author/Creator) - University of Bonn
R.A. Ophoff (Author/Creator) - University of California, Los Angeles
J.K. Buitelaar (Author/Creator) - Radboud University Nijmegen
G. Fernández (Author/Creator) - Radboud University Nijmegen
P.S. Sachdev (Author/Creator) - UNSW Sydney
M. Rietschel (Author/Creator) - Heidelberg University
N.E.M. van Haren (Author/Creator) - Utrecht University
S.E. Fisher (Author/Creator) - Radboud University Nijmegen
A.S. Beiser (Author/Creator) - Boston University
C. Francks (Author/Creator) - Radboud University Nijmegen
A.J. Saykin (Author/Creator) - Indiana University
K.A. Mather (Author/Creator) - UNSW Sydney
N. Romanczuk-Seiferth (Author/Creator) - Charité - Universitätsmedizin Berlin
C.A. Hartman (Author/Creator) - University of Groningen
A.L. DeStefano (Author/Creator) - Boston University
D.J. Heslenfeld (Author/Creator) - Vrije Universiteit Amsterdam
M.W. Weiner (Author/Creator) - University of California, San Francisco
H. Walter (Author/Creator) - Humboldt-Universität zu Berlin
P.J. Hoekstra (Author/Creator) - University of Groningen
P.A. Nyquist (Author/Creator) - Johns Hopkins Medicine
B. Franke (Author/Creator) - Radboud University Nijmegen
D.A. Bennett (Author/Creator) - Rush University Medical Center
H.J. Grabe (Author/Creator) - Universitätsmedizin Greifswald
A.D. Johnson (Author/Creator)
C. Chen (Author/Creator) - National University of Singapore
C.M. van Duijn (Author/Creator) - Leiden University
O.L. Lopez (Author/Creator) - University of Pittsburgh
M. Fornage (Author/Creator) - The University of Texas Health Science Center at Houston
J.M. Wardlaw (Author/Creator) - University of Edinburgh
R. Schmidt (Author/Creator) - Medical University of Graz
C. DeCarli (Author/Creator) - University of California, Davis
P.L. De Jager (Author/Creator) - Columbia University
A. Villringer (Author/Creator) - Max Planck Society
S. Debette (Author/Creator) - Université de Bordeaux
V. Gudnason (Author/Creator) - University of Iceland
S.E. Medland (Author/Creator)
J.M. Shulman (Author/Creator) - Baylor College of Medicine
P.M. Thompson (Author/Creator) - University of Southern California
S. Seshadri (Author/Creator) - Boston University
M.A. Ikram (Author/Creator) - Erasmus University Rotterdam
Publication Details: Nature Genetics, Vol.51(11), pp.1624-1636
Publisher: Nature Publishing Group
Identifiers: 991005542055207891
Copyright: © 2019 Springer Nature Limited
Murdoch Affiliation: Information Technology, Mathematics and Statistics
Language: English
Resource Type: Journal article

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