Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

E. Hofer; G.V. Roshchupkin; H.H.H. Adams; M.J. Knol; H. Lin; S. Li; H. Zare; S. Ahmad; N.J. Armstrong; C.L. Satizabal; M. Bernard; J.C. Bis; N.A. Gillespie; M. Luciano; A. Mishra; M. Scholz; A. Teumer; R. Xia; X. Jian; T.H. Mosley; Y. Saba; L. Pirpamer; S. Seiler; J.T. Becker; O. Carmichael; J.I. Rotter; B.M. Psaty; O.L. Lopez; N. Amin; S.J. van der Lee; Q. Yang; J.J. Himali; P. Maillard; A.S. Beiser; C. DeCarli; S. Karama; L. Lewis; M. Harris; M.E. Bastin; I.J. Deary; A. Veronica Witte; F. Beyer; M. Loeffler; K.A. Mather; P.R. Schofield; A. Thalamuthu; J.B. Kwok; M.J. Wright; D. Ames; J. Trollor; J. Jiang; H. Brodaty; W. Wen; M.W. Vernooij; A. Hofman; A.G. Uitterlinden; W.J. Niessen; K. Wittfeld; R. Bülow; U. Völker; Z. Pausova; G. Bruce Pike; S. Maingault; F. Crivello; C. Tzourio; P. Amouyel; B. Mazoyer; M.C. Neale; C.E. Franz; M.J. Lyons; M.S. Panizzon; O.A. Andreassen; A.M. Dale; M.A. Logue; K.L. Grasby; N. Jahanshad; J.N. Painter; L. Colodro-Conde; J. Bralten; D.P. Hibar; P.A. Lind; F. Pizzagalli; J.L. Stein; P.M. Thompson; S.E. Medland; P.S. Sachdev; W.S. Kremen; J.M. Wardlaw; A. Villringer; C.M. van Duijn; H.J. Grabe; W.T. Longstreth; M. Fornage; T. Paus; S. Debette; M. Arfan Ikram; H. Schmidt; R. Schmidt; S. Seshadri

doi:10.1038/s41467-020-18367-y

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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

E. Hofer, G.V. Roshchupkin, H.H.H. Adams, M.J. Knol, H. Lin, S. Li, H. Zare, S. Ahmad, N.J. Armstrong, C.L. Satizabal, …

Nature Communications, Vol.11(1), Art. 4796

2020

DOI: https://doi.org/10.1038/s41467-020-18367-y

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Abstract

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

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Title: Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Authors/Creators: E. Hofer (Author/Creator) - Medical University of Graz
G.V. Roshchupkin (Author/Creator) - Erasmus University Rotterdam
H.H.H. Adams (Author/Creator) - Erasmus University Rotterdam
M.J. Knol (Author/Creator) - Erasmus University Rotterdam
H. Lin (Author/Creator) - Boston University
S. Li (Author/Creator) - Boston University
H. Zare (Author/Creator) - The University of Texas Health Science Center at San Antonio
S. Ahmad (Author/Creator) - Erasmus University Rotterdam
N.J. Armstrong (Author/Creator) - Murdoch University
C.L. Satizabal (Author/Creator) - Boston University
M. Bernard (Author/Creator)
J.C. Bis (Author/Creator)
N.A. Gillespie (Author/Creator)
M. Luciano (Author/Creator)
A. Mishra (Author/Creator)
M. Scholz (Author/Creator)
A. Teumer (Author/Creator)
R. Xia (Author/Creator)
X. Jian (Author/Creator)
T.H. Mosley (Author/Creator)
Y. Saba (Author/Creator)
L. Pirpamer (Author/Creator)
S. Seiler (Author/Creator)
J.T. Becker (Author/Creator)
O. Carmichael (Author/Creator)
J.I. Rotter (Author/Creator)
B.M. Psaty (Author/Creator)
O.L. Lopez (Author/Creator)
N. Amin (Author/Creator)
S.J. van der Lee (Author/Creator)
Q. Yang (Author/Creator)
J.J. Himali (Author/Creator)
P. Maillard (Author/Creator)
A.S. Beiser (Author/Creator)
C. DeCarli (Author/Creator)
S. Karama (Author/Creator)
L. Lewis (Author/Creator)
M. Harris (Author/Creator)
M.E. Bastin (Author/Creator)
I.J. Deary (Author/Creator)
A. Veronica Witte (Author/Creator)
F. Beyer (Author/Creator)
M. Loeffler (Author/Creator)
K.A. Mather (Author/Creator)
P.R. Schofield (Author/Creator)
A. Thalamuthu (Author/Creator)
J.B. Kwok (Author/Creator)
M.J. Wright (Author/Creator) - The University of Queensland
D. Ames (Author/Creator)
J. Trollor (Author/Creator)
J. Jiang (Author/Creator)
H. Brodaty (Author/Creator)
W. Wen (Author/Creator)
M.W. Vernooij (Author/Creator)
A. Hofman (Author/Creator)
A.G. Uitterlinden (Author/Creator)
W.J. Niessen (Author/Creator)
K. Wittfeld (Author/Creator)
R. Bülow (Author/Creator)
U. Völker (Author/Creator)
Z. Pausova (Author/Creator)
G. Bruce Pike (Author/Creator)
S. Maingault (Author/Creator)
F. Crivello (Author/Creator)
C. Tzourio (Author/Creator)
P. Amouyel (Author/Creator)
B. Mazoyer (Author/Creator)
M.C. Neale (Author/Creator)
C.E. Franz (Author/Creator)
M.J. Lyons (Author/Creator)
M.S. Panizzon (Author/Creator) - University of California San Diego
O.A. Andreassen (Author/Creator) - University of Oslo
A.M. Dale (Author/Creator) - University of California San Diego
M.A. Logue (Author/Creator)
K.L. Grasby (Author/Creator) - QIMR Berghofer Medical Research Institute
N. Jahanshad (Author/Creator)
J.N. Painter (Author/Creator)
L. Colodro-Conde (Author/Creator)
J. Bralten (Author/Creator)
D.P. Hibar (Author/Creator)
P.A. Lind (Author/Creator)
F. Pizzagalli (Author/Creator)
J.L. Stein (Author/Creator)
P.M. Thompson (Author/Creator) - University of Southern California
S.E. Medland (Author/Creator)
P.S. Sachdev (Author/Creator)
W.S. Kremen (Author/Creator)
J.M. Wardlaw (Author/Creator)
A. Villringer (Author/Creator)
C.M. van Duijn (Author/Creator) - University of Oxford
H.J. Grabe (Author/Creator) - Universität Greifswald
W.T. Longstreth (Author/Creator) - University of Washington
M. Fornage (Author/Creator) - The University of Texas Health Science Center at Houston
T. Paus (Author/Creator) - University of Toronto
S. Debette (Author/Creator) - Université de Bordeaux
M. Arfan Ikram (Author/Creator)
H. Schmidt (Author/Creator) - Medical University of Graz
R. Schmidt (Author/Creator) - Medical University of Graz
S. Seshadri (Author/Creator) - Boston University
Publication Details: Nature Communications, Vol.11(1), Art. 4796
Publisher: Springer Nature
Identifiers: 991005542426107891
Copyright: © 2020 Springer Nature Limited
Murdoch Affiliation: Information Technology, Mathematics and Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.455 Genome-Wide Association Studies
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior