Journal article
Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease
BMC Research Notes, Vol.12(1)
2019
Abstract
Objective
Coronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need to know more about the development and progress of this pathology, including the genetic aspects. Humanin is a small peptide known for its cytoprotective and anti-apoptotic properties. Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.
Results
Lookup from meta-analysis datasets gave single nucleotide polymorphisms in all 13 humanin-like nuclear isoform genes with the lowest P value for rs6151662 from the MTRNR2L2 gene including the 50 kb flanking region in both directions (P-value = 0.0037). Within the gene region alone the top variant was rs78083998 from the MTRNR2L13 region (meta-analysis P-value = 0.042). None of the found associations were statistically significant after correction for multiple testing. Lookup for expression trait loci in these gene regions gave no statistically significant variants.
Details
- Title
- Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease
- Authors/Creators
- M. Eltermaa (Author/Creator) - University of TartuM. Jakobson (Author/Creator) - University of TartuM. Utt (Author/Creator) - University of TartuS. Kõks (Author/Creator) - Murdoch UniversityR. Mägi (Author/Creator) - University of TartuJ. Starkopf (Author/Creator) - Tartu University Hospital
- Publication Details
- BMC Research Notes, Vol.12(1)
- Publisher
- BioMed Central
- Identifiers
- 991005543151907891
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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