Genetic variations in IL28B and allergic disease in children

S. Gaudieri; M. Lucas; A. Lucas; E. McKinnon; H. Albloushi; A. Rauch; J. di Iulio; D. Martino; S.L. Prescott; M.K. Tulic

doi:10.1371/journal.pone.0030607

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Genetic variations in IL28B and allergic disease in children

Journal article

Peer reviewed

Genetic variations in IL28B and allergic disease in children

S. Gaudieri, M. Lucas, A. Lucas, E. McKinnon, H. Albloushi, A. Rauch, J. di Iulio, D. Martino, S.L. Prescott and M.K. Tulic

PLoS ONE, Vol.7(1), e30607

2012

DOI: https://doi.org/10.1371/journal.pone.0030607

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Abstract

Environmental changes affecting the relationship between the developing immune system and microbial exposure have been implicated in the epidemic rise of allergic disease in developed countries. While early developmental differences in T cell function are well-recognised, there is now emerging evidence that this is related to developmental differences in innate immune function. In this study we sought to examine if differences associated with innate immunity contribute to the altered immune programming recognised in allergic children. Here, we describe for the first time, the association of carriage of the T allele of the tagging single nucleotide polymorphism rs12979860 3 kb upstream of IL28B, encoding the potent innate immune modulator type III interferon lambda (IFN-λ3), and allergy in children (p = 0.004; OR 4.56). Strikingly, the association between rs12979860 genotype and allergic disease is enhanced in girls. Furthermore, carriage of the T allele at rs12979860 correlates with differences in the pro-inflammatory profile during the first five years of life suggesting this contributes to the key differences in subsequent innate immune development in children who develop allergic disease. In the context of rising rates of disease, these immunologic differences already present at birth imply very early interaction between genetic predisposition and prenatal environmental influences.

Details

Title: Genetic variations in IL28B and allergic disease in children
Authors/Creators: S. Gaudieri (Author/Creator) - Murdoch University
M. Lucas (Author/Creator) - Murdoch University
A. Lucas (Author/Creator) - Murdoch University
E. McKinnon (Author/Creator) - Murdoch University
H. Albloushi (Author/Creator) - The University of Western Australia
A. Rauch (Author/Creator) - University Hospital of Bern
J. di Iulio (Author/Creator) - University of Lausanne
D. Martino (Author/Creator) - The University of Western Australia
S.L. Prescott (Author/Creator) - The University of Western Australia
M.K. Tulic (Author/Creator) - The University of Western Australia
Publication Details: PLoS ONE, Vol.7(1), e30607
Publisher: Public Library of Science
Identifiers: 991005541921907891
Copyright: © Gaudieri et al
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article
Note: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.125 Hepatitis; 1.125.83 HCV
Web Of Science research areas: Gastroenterology & Hepatology
ESI research areas: Clinical Medicine