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Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning
Journal article   Open access   Peer reviewed

Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning

K. Gregg, B. Hamdorf, K. Henderson, J. Kopecny and C.M. Wong
Applied and Environmental Microbiology, Vol.64(9), pp.3496-3498
1998
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Abstract

Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 10(6) to 10(7) cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control sheep.

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