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Journal article
Genome-Wide Differential Transcription of Long Noncoding RNAs in Psoriatic Skin
International journal of molecular sciences, Vol.24(22), 16344
2023
Abstract
Long noncoding RNAs (lncRNAs) may contribute to the formation of psoriatic lesions. The present study’s objective was to identify long lncRNA genes that are differentially expressed in patient samples of psoriasis through computational analysis techniques. By using previously published RNA sequencing data from psoriatic and healthy patients (n = 324), we analysed the differential expression of lncRNAs to determine transcripts of heightened expression. We computationally screened lncRNA transcripts as annotated by GENCODE across the human genome and compared transcription in psoriatic and healthy samples from two separate studies. We observed 54 differentially expressed genes as seen in two independent datasets collected from psoriasis and healthy patients. We also identified the differential expression of LINC01215 and LINC1206 associated with the cell cycle pathway and psoriasis pathogenesis. SH3PXD2A-AS1 was identified as a participant in the STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop. Both the SH3PXD2A-AS1 and CERNA2 genes have already been recognised as part of the IFN-γ signalling pathway regulation. Additionally, EPHA1-AS1, CYP4Z2P and SNHG12 gene upregulation have all been previously linked to inflammatory skin diseases. Differential expression of various lncRNAs affects the pathogenesis of psoriasis. Further characterisation of lncRNAs and their functions are important for developing our understanding of psoriasis.
Details
- Title
- Genome-Wide Differential Transcription of Long Noncoding RNAs in Psoriatic Skin
- Authors/Creators
- Valerie Stacey - Perron Institute for Neurological and Translational ScienceSulev Kõks - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
- Publication Details
- International journal of molecular sciences, Vol.24(22), 16344
- Publisher
- MDPI AG
- Identifiers
- 991005618764907891
- Copyright
- © 2023 by the authors.
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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