Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

J.C. Barrett; D.G. Clayton; P. Concannon; B. Akolkar; J.D. Cooper; H.A. Erlich; C. Julier; G. Morahan; J. Nerup; C. Nierras; V. Plagnol; F. Pociot; H. Schuilenburg; D.J. Smyth; H. Stevens; J.A. Todd; N.M. Walker; S.S. Rich; S. Gaudieri; I. James; E. McKinnon; D. Nolan

doi:10.1038/ng.381

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Journal article

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

J.C. Barrett, D.G. Clayton, P. Concannon, B. Akolkar, J.D. Cooper, H.A. Erlich, C. Julier, G. Morahan, J. Nerup, C. Nierras, …

Nature Genetics, Vol.41(6), pp.703-707

2009

DOI: https://doi.org/10.1038/ng.381

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Abstract

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

Details

Title: Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Authors/Creators: J.C. Barrett (Author/Creator) - University of Cambridge
D.G. Clayton (Author/Creator) - University of Cambridge
P. Concannon (Author/Creator) - University of Virginia
B. Akolkar (Author/Creator) - National Institute of Diabetes and Digestive and Kidney Diseases
J.D. Cooper (Author/Creator) - University of Cambridge
H.A. Erlich (Author/Creator) - Roche Molecular Systems, Pleasanton, USA
C. Julier (Author/Creator) - Inserm
G. Morahan (Author/Creator) - The University of Western Australia
J. Nerup (Author/Creator) - Steno Diabetes Centers
C. Nierras (Author/Creator) - Breakthrough T1D
V. Plagnol (Author/Creator) - University of Cambridge
F. Pociot (Author/Creator) - Steno Diabetes Centers
H. Schuilenburg (Author/Creator) - University of Cambridge
D.J. Smyth (Author/Creator) - University of Cambridge
H. Stevens (Author/Creator) - University of Cambridge
J.A. Todd (Author/Creator) - University of Cambridge
N.M. Walker (Author/Creator) - University of Cambridge
S.S. Rich (Author/Creator) - University of Virginia
S. Gaudieri (Author/Creator)
I. James (Author/Creator)
E. McKinnon (Author/Creator)
D. Nolan (Author/Creator)
Publication Details: Nature Genetics, Vol.41(6), pp.703-707
Publisher: Nature Publishing Group
Identifiers: 991005540849107891
Copyright: © 2017 Macmillan Publishers Limited
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article
Additional Information: Murdoch University authors made contribution to this work as part of the Type 1 Diabetes Genetics Consortium

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.26 Diabetes; 1.26.1016 Type 1 Diabetes
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics