Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

J. Lahti; S. Tuominen; Q. Yang; G. Pergola; S. Ahmad; N. Amin; N.J. Armstrong; A. Beiser; K. Bey; J.C. Bis; E. Boerwinkle; J. Bressler; A. Campbell; H. Campbell; Q. Chen; J. Corley; S.R. Cox; G. Davies; P.L. De Jager; E.M. Derks; J.D. Faul; A.L. Fitzpatrick; A.E. Fohner; I. Ford; M. Fornage; Z. Gerring; H.J. Grabe; F. Grodstein; V. Gudnason; E. Simonsick; E.G. Holliday; P.K. Joshi; E. Kajantie; J. Kaprio; P. Karell; L. Kleineidam; M.J. Knol; N.A. Kochan; J.B. Kwok; M. Leber; M. Lam; T. Lee; S. Li; A. Loukola; T. Luck; R.E. Marioni; K.A. Mather; S. Medland; S.S. Mirza; M.A. Nalls; K. Nho; A. O’Donnell; C. Oldmeadow; J. Painter; A. Pattie; S. Reppermund; S.L. Risacher; R.J. Rose; V. Sadashivaiah; M. Scholz; C.L. Satizabal; P.W. Schofield; K.E. Schraut; R.J. Scott; J. Simino; A.V. Smith; J.A. Smith; D.J. Stott; I. Surakka; A. Teumer; A. Thalamuthu; S. Trompet; S.T. Turner; S.J. van der Lee; A. Villringer; U. Völker; R.S. Wilson; K. Wittfeld; E. Vuoksimaa; R. Xia; K. Yaffe; L. Yu; H. Zare; W. Zhao; D. Ames; J. Attia; D.A. Bennett; H. Brodaty; D.I. Chasman; A.L. Goldman; C. Hayward; M.A. Ikram; J.W. Jukema; S.L.R. Kardia; T. Lencz; M. Loeffler; V.S. Mattay; A. Palotie; B.M. Psaty; A. Ramirez; P.M. Ridker; S.G. Riedel-Heller; P.S. Sachdev; A.J. Saykin; M. Scherer; P.R. Schofield; S. Sidney; J.M. Starr; J. Trollor; W. Ulrich; M. Wagner; D.R. Weir; J.F. Wilson; M.J. Wright; D.R. Weinberger; S. Debette; J.G. Eriksson; T.H. Mosley; L.J. Launer; C.M. van Duijn; I.J. Deary; S. Seshadri; K. Räikkönen

doi:10.1038/s41380-022-01710-8

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Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

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Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

J. Lahti, S. Tuominen, Q. Yang, G. Pergola, S. Ahmad, N. Amin, N.J. Armstrong, A. Beiser, K. Bey, J.C. Bis, …

Molecular Psychiatry

2022

DOI: https://doi.org/10.1038/s41380-022-01710-8

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Abstract

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Details

Title: Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
Authors/Creators: J. Lahti (Author/Creator)
S. Tuominen (Author/Creator)
Q. Yang (Author/Creator)
G. Pergola (Author/Creator)
S. Ahmad (Author/Creator)
N. Amin (Author/Creator)
N.J. Armstrong (Author/Creator)
A. Beiser (Author/Creator)
K. Bey (Author/Creator)
J.C. Bis (Author/Creator)
E. Boerwinkle (Author/Creator)
J. Bressler (Author/Creator)
A. Campbell (Author/Creator)
H. Campbell (Author/Creator)
Q. Chen (Author/Creator)
J. Corley (Author/Creator)
S.R. Cox (Author/Creator)
G. Davies (Author/Creator)
P.L. De Jager (Author/Creator)
E.M. Derks (Author/Creator)
J.D. Faul (Author/Creator)
A.L. Fitzpatrick (Author/Creator)
A.E. Fohner (Author/Creator)
I. Ford (Author/Creator)
M. Fornage (Author/Creator)
Z. Gerring (Author/Creator)
H.J. Grabe (Author/Creator)
F. Grodstein (Author/Creator)
V. Gudnason (Author/Creator)
E. Simonsick (Author/Creator)
E.G. Holliday (Author/Creator)
P.K. Joshi (Author/Creator)
E. Kajantie (Author/Creator)
J. Kaprio (Author/Creator)
P. Karell (Author/Creator)
L. Kleineidam (Author/Creator)
M.J. Knol (Author/Creator)
N.A. Kochan (Author/Creator)
J.B. Kwok (Author/Creator)
M. Leber (Author/Creator)
M. Lam (Author/Creator)
T. Lee (Author/Creator)
S. Li (Author/Creator)
A. Loukola (Author/Creator)
T. Luck (Author/Creator)
R.E. Marioni (Author/Creator)
K.A. Mather (Author/Creator)
S. Medland (Author/Creator)
S.S. Mirza (Author/Creator)
M.A. Nalls (Author/Creator)
K. Nho (Author/Creator)
A. O’Donnell (Author/Creator)
C. Oldmeadow (Author/Creator)
J. Painter (Author/Creator)
A. Pattie (Author/Creator)
S. Reppermund (Author/Creator)
S.L. Risacher (Author/Creator)
R.J. Rose (Author/Creator)
V. Sadashivaiah (Author/Creator)
M. Scholz (Author/Creator)
C.L. Satizabal (Author/Creator)
P.W. Schofield (Author/Creator)
K.E. Schraut (Author/Creator)
R.J. Scott (Author/Creator)
J. Simino (Author/Creator)
A.V. Smith (Author/Creator)
J.A. Smith (Author/Creator)
D.J. Stott (Author/Creator)
I. Surakka (Author/Creator)
A. Teumer (Author/Creator)
A. Thalamuthu (Author/Creator)
S. Trompet (Author/Creator)
S.T. Turner (Author/Creator)
S.J. van der Lee (Author/Creator)
A. Villringer (Author/Creator)
U. Völker (Author/Creator)
R.S. Wilson (Author/Creator)
K. Wittfeld (Author/Creator)
E. Vuoksimaa (Author/Creator)
R. Xia (Author/Creator)
K. Yaffe (Author/Creator)
L. Yu (Author/Creator)
H. Zare (Author/Creator)
W. Zhao (Author/Creator)
D. Ames (Author/Creator)
J. Attia (Author/Creator)
D.A. Bennett (Author/Creator)
H. Brodaty (Author/Creator)
D.I. Chasman (Author/Creator)
A.L. Goldman (Author/Creator)
C. Hayward (Author/Creator)
M.A. Ikram (Author/Creator)
J.W. Jukema (Author/Creator)
S.L.R. Kardia (Author/Creator)
T. Lencz (Author/Creator)
M. Loeffler (Author/Creator)
V.S. Mattay (Author/Creator)
A. Palotie (Author/Creator)
B.M. Psaty (Author/Creator)
A. Ramirez (Author/Creator)
P.M. Ridker (Author/Creator)
S.G. Riedel-Heller (Author/Creator)
P.S. Sachdev (Author/Creator)
A.J. Saykin (Author/Creator)
M. Scherer (Author/Creator)
P.R. Schofield (Author/Creator)
S. Sidney (Author/Creator)
J.M. Starr (Author/Creator)
J. Trollor (Author/Creator)
W. Ulrich (Author/Creator)
M. Wagner (Author/Creator)
D.R. Weir (Author/Creator)
J.F. Wilson (Author/Creator)
M.J. Wright (Author/Creator)
D.R. Weinberger (Author/Creator)
S. Debette (Author/Creator)
J.G. Eriksson (Author/Creator)
T.H. Mosley (Author/Creator)
L.J. Launer (Author/Creator)
C.M. van Duijn (Author/Creator)
I.J. Deary (Author/Creator)
S. Seshadri (Author/Creator)
K. Räikkönen (Author/Creator)
Publication Details: Molecular Psychiatry
Publisher: Nature Publishing Group
Identifiers: 991005541863807891
Murdoch Affiliation: School of Mathematics, Statistics, Chemistry and Physics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.455 Genome-Wide Association Studies
Web Of Science research areas: Biochemistry & Molecular Biology; Neurosciences; Psychiatry
ESI research areas: Neuroscience & Behavior