Genome‐wide profile in DNA methylation in goat ovaries of two different litter size populations

B. Kang; J. Wang; H. Zhang; W. Shen; O. El‐Mahdy Othman; Y. Zhao; L. Min

doi:10.1111/jpn.13600

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Journal article

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Genome‐wide profile in DNA methylation in goat ovaries of two different litter size populations

B. Kang, J. Wang, H. Zhang, W. Shen, O. El‐Mahdy Othman, Y. Zhao and L. Min

Journal of Animal Physiology and Animal Nutrition, Vol.106(2), pp.239-249

2022

DOI: https://doi.org/10.1111/jpn.13600

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Abstract

Although some studies have investigated the DNA methylation modification in goat ovaries, it is not understood DNA methylation related to goat litter size. This investigation was designed to explore the DNA methylation status in the ovaries of high litter size and low litter size groups using whole-genome bisulfite sequencing (WGBS). We found that there was global difference on DNA methylation in high litter size and low litter size goat ovaries. Many differentially methylated region-related genes (DMGs) were found in the ovaries of these two different goat populations. Moreover, enrichment analysis discovered that many DMGs were involved in gamete development, reproductive system development, wingless-type MMTV integration site family (WNT) signalling pathways and mitogen-activated protein kinase 1 (MAPK) signalling pathways. The data indicated that DNA methylation in goat ovaries may play important roles in the folliculogenesis, the oocyte ovulation rate and finally the litter size. This study provides a comprehensive analysis of genome-wide DNA methylation patterns in ovaries of high and low litter size goat which helps the understanding of ovarian DNA methylation in relation to goat fertility capability.

Details

Title: Genome‐wide profile in DNA methylation in goat ovaries of two different litter size populations
Authors/Creators: B. Kang (Author/Creator) - Qingdao Agricultural University
J. Wang (Author/Creator) - Qingdao Agricultural University
H. Zhang (Author/Creator) - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
W. Shen (Author/Creator) - Qingdao Agricultural University
O. El‐Mahdy Othman (Author/Creator)
Y. Zhao (Author/Creator) - Qingdao Agricultural University
L. Min (Author/Creator) - Qingdao Agricultural University
Publication Details: Journal of Animal Physiology and Animal Nutrition, Vol.106(2), pp.239-249
Publisher: Wiley
Identifiers: 991005542746107891
Copyright: © 2021 Wiley-VCH GmbH
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.100 Epigenetic Regulation
Web Of Science research areas: Agriculture, Dairy & Animal Science; Veterinary Sciences
ESI research areas: Plant & Animal Science