Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot (Isoodon obesulus) in Western Australia

M.D. Bennett; L. Woolford; H. Stevens; M. Van Ranst; T. Oldfield; M. Slaven; A.J. O'Hara; K.S. Warren; P.K. Nicholls

doi:10.1016/j.virol.2008.03.014

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Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot (Isoodon obesulus) in Western Australia

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Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot (Isoodon obesulus) in Western Australia

M.D. Bennett, L. Woolford, H. Stevens, M. Van Ranst, T. Oldfield, M. Slaven, A.J. O'Hara, K.S. Warren and P.K. Nicholls

Virology, Vol.376(1), pp.173-182

2008

DOI: https://doi.org/10.1016/j.virol.2008.03.014

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Abstract

The genome of a novel virus, tentatively named bandicoot papillomatosis carcinomatosis virus type 2 (BPCV2), obtained from multicentric papillomatous lesions from an adult male southern brown bandicoot (Isoodon obesulus) was sequenced in its entirety. BPCV2 had a circular double-stranded DNA genome consisting of 7277 bp and open reading frames encoding putative L1 and L2 structural proteins and putative large T antigen and small t antigen transforming proteins. These genomic features, intermediate between Papillomaviridae and Polyomaviridae are most similar to BPCV1, recently described from papillomas and carcinomas in the endangered western barred bandicoot (Perameles bougainville). This study also employed in situ hybridization to definitively demonstrate BPCV2 DNA within lesion biopsies. The discovery of BPCV2 provides evidence of virus-host co-speciation between BPCVs and marsupial bandicoots and has important implications for the phylogeny and taxonomy of circular double-stranded DNA viruses infecting vertebrates.

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Title: Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot (Isoodon obesulus) in Western Australia
Authors/Creators: M.D. Bennett (Author/Creator) - Murdoch University
L. Woolford (Author/Creator) - Murdoch University
H. Stevens (Author/Creator) - Rega Institute for Medical Research
M. Van Ranst (Author/Creator) - Rega Institute for Medical Research
T. Oldfield (Author/Creator) - Veterinary Medical Center
M. Slaven (Author/Creator) - Murdoch University
A.J. O'Hara (Author/Creator) - Murdoch University
K.S. Warren (Author/Creator) - Murdoch University
P.K. Nicholls (Author/Creator) - Murdoch University
Publication Details: Virology, Vol.376(1), pp.173-182
Publisher: Elsevier
Identifiers: 991005540358307891
Copyright: © 2008 Elsevier Inc. All rights reserved.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.179 Oncology; 1.179.108 HPV and Cervical Cancer
Web Of Science research areas: Virology
ESI research areas: Microbiology