Journal article
Genomic evolution and polymorphism: Segmental duplications and haplotypes at 108 regions on 21 chromosomes
Genomics, Vol.102(1), pp.15-26
2013
Abstract
We describe here extensive, previously unknown, genomic polymorphism in 120 regions, covering 19 autosomes and both sex chromosomes. Each contains duplication within multigene clusters. Of these, 108 are extremely polymorphic with multiple haplotypes.We used the genomic matching technique (GMT), previously used to characterise the major histocompatibility complex (MHC) and regulators of complement activation (RCA).This genome-wide extension of this technique enables the examination of many underlying cis, trans and epistatic interactions responsible for phenotypic differences especially in relation to individuality, evolution and disease susceptibility.The extent of the diversity could not have been predicted and suggests a new model of primate evolution based on conservation of polymorphism rather than de novo mutation.
Details
- Title
- Genomic evolution and polymorphism: Segmental duplications and haplotypes at 108 regions on 21 chromosomes
- Authors/Creators
- C.A. McLure (Author/Creator)P. Hinchliffe (Author/Creator)S. Lester (Author/Creator)J.F. Williamson (Author/Creator)J.A. Millman (Author/Creator)P.J. Keating (Author/Creator)B.J. Stewart (Author/Creator)R.L. Dawkins (Author/Creator)
- Publication Details
- Genomics, Vol.102(1), pp.15-26
- Publisher
- Academic Press
- Identifiers
- 991005544752507891
- Copyright
- © 2013 Elsevier Inc.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Biotechnology & Applied Microbiology
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics