Genomic hypomethylation in neoplastic cells from dogs with malignant lymphoproliferative disorders

J.T. Pelham; P.J. Irwin; P.H. Kay

doi:10.1016/S0034-5288(02)00179-0

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Genomic hypomethylation in neoplastic cells from dogs with malignant lymphoproliferative disorders

Journal article

Peer reviewed

Genomic hypomethylation in neoplastic cells from dogs with malignant lymphoproliferative disorders

J.T. Pelham, P.J. Irwin and P.H. Kay

Research in Veterinary Science, Vol.74(1), pp.101-104

2003

DOI: https://doi.org/10.1016/S0034-5288(02)00179-0

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Abstract

DNA methylation is an epigenetic modification in which a methyl group is added usually to the fifth carbon position of a cytosine residue. Dysregulation of this process is an important molecular event which has been shown to be associated with neoplastic transformation and tumour progression in humans and mice. Features of methylation dysregulation in many different types of neoplasms include general genomic hypomethylation, focal hypermethylation, and altered expression of genes which encode a series of DNA (cytosine-5) methyltransferases. Interestingly, many types of neoplasia that are recognised in humans also develop spontaneously in the dog. By comparing the restriction patterns of MspI and HpaII, this study demonstrates that as in human, genomic hypomethylation is a feature of neoplastic cells in the majority of canine lymphoma cases and approximately one-third of canine leukemia cases confirming that dysregulation of the DNA methylating machinery is implicated in malignant transformation of lymphoid cells in some dogs.

Details

Title: Genomic hypomethylation in neoplastic cells from dogs with malignant lymphoproliferative disorders
Authors/Creators: J.T. Pelham (Author/Creator) - The University of Western Australia
P.J. Irwin (Author/Creator) - Murdoch University
P.H. Kay (Author/Creator) - The University of Western Australia
Publication Details: Research in Veterinary Science, Vol.74(1), pp.101-104
Publisher: Elsevier
Identifiers: 991005545025107891
Copyright: © 2002 Elsevier Science Ltd.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.100 Epigenetic Regulation
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science