Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus: Blurring of the traditional definitions

A.M. Bal; G.W. Coombs; M.T.G. Holden; J.A. Lindsay; G.R. Nimmo; P. Tattevin; R.L. Skov

doi:10.1016/j.jgar.2016.04.004

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Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus: Blurring of the traditional definitions

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Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus: Blurring of the traditional definitions

A.M. Bal, G.W. Coombs, M.T.G. Holden, J.A. Lindsay, G.R. Nimmo, P. Tattevin and R.L. Skov

Journal of Global Antimicrobial Resistance, Vol.6, pp.95-101

2016

DOI: https://doi.org/10.1016/j.jgar.2016.04.004

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Abstract

The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification. © 2016 International Society for Chemotherapy of Infection and Cancer.

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Title: Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus: Blurring of the traditional definitions
Authors/Creators: A.M. Bal (Author/Creator) - University Hospital Crosshouse
G.W. Coombs (Author/Creator) - Fiona Stanley Hospital
M.T.G. Holden (Author/Creator) - University of St Andrews
J.A. Lindsay (Author/Creator) - St George's, University of London
G.R. Nimmo (Author/Creator) - Griffith University
P. Tattevin (Author/Creator) - Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 35033 Rennes, France
R.L. Skov (Author/Creator) - Statens Serum Institut
Publication Details: Journal of Global Antimicrobial Resistance, Vol.6, pp.95-101
Publisher: Elsevier BV
Identifiers: 991005542762107891
Copyright: © 2016 International Society for Chemotherapy of Infection and Cancer.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.173 MRSA and VRE
Web Of Science research areas: Infectious Diseases; Pharmacology & Pharmacy
ESI research areas: Immunology