Genomic sequence analysis of the 238-kb swine segment with a cluster of TRIM and olfactory receptor genes located, but with no class I genes, at the distal end of the SLA class I region

A. Ando; A. Shigenari; J.K. Kulski; C. Renard; P. Chardon; T. Shiina; H. Inoko

doi:10.1007/s00251-005-0053-6

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Genomic sequence analysis of the 238-kb swine segment with a cluster of TRIM and olfactory receptor genes located, but with no class I genes, at the distal end of the SLA class I region

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Genomic sequence analysis of the 238-kb swine segment with a cluster of TRIM and olfactory receptor genes located, but with no class I genes, at the distal end of the SLA class I region

A. Ando, A. Shigenari, J.K. Kulski, C. Renard, P. Chardon, T. Shiina and H. Inoko

Immunogenetics, Vol.57(11), pp.864-873

2005

DOI: https://doi.org/10.1007/s00251-005-0053-6

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Abstract

Continuous genomic sequence has been previously determined for the swine leukocyte antigen (SLA) class I region from the TNF gene cluster at the border between the major histocompatibility complex (MHC) class III and class I regions to the UBD gene at the telomeric end of the classical class I gene cluster (SLA-1 to SLA-5, SLA-9, SLA-11). To complete the genomic sequence of the entire SLA class I genomic region, we have analyzed the genomic sequences of two BAC clones carrying a continuous 237,633-bp-long segment spanning from the TRIM15 gene to the UBD gene located on the telomeric side of the classical SLA class I gene cluster. Fifteen non-class I genes, including the zinc finger and the tripartite motif (TRIM) ring-finger-related family genes and olfactory receptor genes, were identified in the 238-kilobase (kb) segment, and their location in the segment was similar to their apparent human homologs. In contrast, a human segment (alpha block) spanning about 375 kb from the gene ETF1P1 and from the HLA-J to HLA-F genes was absent from the 238-kb swine segment. We conclude that the gene organization of the MHC non-class I genes located in the telomeric side of the classical SLA class I gene cluster is remarkably similar between the swine and the human segments, although the swine lacks a 375-kb segment corresponding to the human alpha block.

Details

Title: Genomic sequence analysis of the 238-kb swine segment with a cluster of TRIM and olfactory receptor genes located, but with no class I genes, at the distal end of the SLA class I region
Authors/Creators: A. Ando (Author/Creator) - Tokai University
A. Shigenari (Author/Creator) - Tokai University
J.K. Kulski (Author/Creator) - Tokai University
C. Renard (Author/Creator) - Institut National de la Recherche Agronomique
P. Chardon (Author/Creator) - Institut National de la Recherche Agronomique
T. Shiina (Author/Creator) - Tokai University
H. Inoko (Author/Creator) - Tokai University
Publication Details: Immunogenetics, Vol.57(11), pp.864-873
Publisher: Springer-Verlag
Identifiers: 991005540263907891
Copyright: © Springer-Verlag 2005.
Murdoch Affiliation: School of Information Technology
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Genetics & Heredity; Immunology
ESI research areas: Immunology