Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1

W.K. Greene; E. Baker; T.H. Rabbitts; U.R. Kees

doi:10.1016/S0378-1119(99)00125-0

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Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1

Journal article

Peer reviewed

Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1

W.K. Greene, E. Baker, T.H. Rabbitts and U.R. Kees

Gene, Vol.232(2), pp.203-207

1999

DOI: https://doi.org/10.1016/S0378-1119(99)00125-0

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Abstract

Human SLIM1 is a recently described gene of the LIM-only class encoding four and a half tandemly repeated LIM domains. LIM domains are double zinc finger structures which provide an interface for protein/protein interactions and are conserved in a variety of nuclear and cytoplasmic factors important in cell fate determination and cellular regulation. Here we report the structural organization, expression pattern and chromosomal localization of the human SLIM1 gene. SLIM1 was found to contain at least five exons with all four introns disrupting the coding region at a similar position relative to the respective complete LIM domains. Northern blot analysis confirmed strikingly high expression of SLIM1 in skeletal muscle and heart, with much lower expression observed in several other tissues including colon, small intestine and prostate. The SLIM1 gene was assigned to human chromosome Xq26 using fluorescence in situ hybridization.

Details

Title: Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1
Authors/Creators: W.K. Greene (Author/Creator) - The Kids Research Institute Australia
E. Baker (Author/Creator) - Women's and Children's Hospital
T.H. Rabbitts (Author/Creator) - MRC Laboratory of Molecular Biology
U.R. Kees (Author/Creator) - The Kids Research Institute Australia
Publication Details: Gene, Vol.232(2), pp.203-207
Publisher: Elsevier BV
Identifiers: 991005540698207891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.123 Protein Stucture, Folding & Modelling; 2.123.2214 Ribonucleases
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics