Journal article
Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential
Journal of Biological Chemistry, Vol.289(38), pp.26075-26088
2014
Abstract
Background: The results of serial passage of BSE in sheep are unknown.
Results: In vitro modeling shows a sheep genotype-dependent switch in prion protein type and loss of the ability to convert human prion protein.
Conclusion: Molecular evolution of sheep BSE prions in vitro is genotype-dependent and affects zoonotic potential.
Significance: Zoonotic risk might be predicted from cell-free modeling.
Details
- Title
- Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential
- Authors/Creators
- Z. Krejciova (Author/Creator)M.A. Barria (Author/Creator)M. Jones (Author/Creator)J.W. Ironside (Author/Creator)M. Jeffrey (Author/Creator)L. González (Author/Creator)M.W. Head (Author/Creator)
- Publication Details
- Journal of Biological Chemistry, Vol.289(38), pp.26075-26088
- Publisher
- American Society for Biochemistry and Molecular Biology Inc.
- Identifiers
- 991005540563907891
- Copyright
- © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.992 Prion Pathogenesis
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Biology & Biochemistry