Journal article
Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study
Brain and Behavior, Vol.10(4), Art. e01579
2020
Abstract
Background
Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and child cognition. The aim was to quantify the relationship between global DNA methylation and cognition and behavior at 4 years of age.
Methods
Child behavior and cognition were measured at age 4 years using the Wechsler Preschool and Primary Scale of Intelligence, third version (WPPSI‐III), and Child Behavior Checklist (CBC). Global DNA methylation (%5‐methylcytosines (%5mC)) was measured in buccal cells at age 4 years, using an enzyme‐linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships.
Results
Data were collected from 73 children recruited from the Women and Their Children's Health (WATCH) study. No statistically significant associations were found between global DNA methylation levels and child cognition or behavior (p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)).
Conclusion
No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta‐analyses.
Details
- Title
- Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study
- Authors/Creators
- R.M. Taylor (Author/Creator) - University of Newcastle AustraliaR. Smith (Author/Creator) - University of Newcastle AustraliaC.E. Collins (Author/Creator) - University of Newcastle AustraliaD. Mossman (Author/Creator) - John Hunter HospitalM.W. Wong‐Brown (Author/Creator)E‐C Chan (Author/Creator)T‐J Evans (Author/Creator)J.R. Attia (Author/Creator) - University of Newcastle AustraliaN. Buckley (Author/Creator) - Murdoch UniversityK. Drysdale (Author/Creator) - University of Newcastle AustraliaT. Smith (Author/Creator) - University of Newcastle AustraliaT. Butler (Author/Creator) - University of Newcastle AustraliaA.J. Hure (Author/Creator) - University of Newcastle Australia
- Publication Details
- Brain and Behavior, Vol.10(4), Art. e01579
- Publisher
- Wiley Periodicals, Inc.
- Identifiers
- 991005543945507891
- Copyright
- © 2020 The Authors.
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.54 Molecular & Cell Biology - Genetics
- 1.54.100 Epigenetic Regulation
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior