Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

T. Paus; S. Seshadri; Z. Pausova; N. Sestan; N. Jahanshad; L. Ding; W.S. Kremen; C.E. Franz; N.A. Gillespie; S. Debette; S. Maingault; A. Mishra; C. Tzourio; H.J. Grabe; R. Bülow; K. Wittfeld; S. van der -Palitschka; S. Frenzel; M.A. Ikram; H.H.H.H. Adams; T.E. Evans; N. Terzikhan; P.S. Sachdev; W. Wen; H. Brodaty; M.J. Wright; J.N. Trollor; A. Thalamuthu; P.R. Schofield; J.B. Kwok; J. Jiang; D. Ames; K.A. Mather; N.J. Armstrong; A. Villringer; F. Beyer; A.V. Witte; M. Loeffler; M. Scholz; I.E. Deary; J.M. Wardlaw; M.A. Harris; M.E. Bastin; L. Lewis; S. Karama; M. Luciano; Q. Yang; S. Li; J.C. Bis; B. Mazoyer; F. Crivello; A. Carrion-Castillo; H. Schmidt; R. Schmidt; L. Pirpamer; Y. Saba; M. Fornage; T.H. Mosley; R. Gottesman; X. Jian; A.M.M. Sousa; G.V. Roshchupkin; S. Tilley; D.E. Vosberg; Y. Patel; E. Hofer; S. Ma; J. Shin

doi:10.1093/cercor/bhaa035

Back

Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

Journal article

Peer reviewed

Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

T. Paus, S. Seshadri, Z. Pausova, N. Sestan, N. Jahanshad, L. Ding, W.S. Kremen, C.E. Franz, N.A. Gillespie, S. Debette, …

Cerebral Cortex, Vol.30(7), pp.4121-4139

2020

DOI: https://doi.org/10.1093/cercor/bhaa035

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade—albeit in a very limited manner—to behaviors as complex as the choice of one’s occupation.

Details

Title: Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes
Authors/Creators: T. Paus (Author/Creator)
S. Seshadri (Author/Creator)
Z. Pausova (Author/Creator)
N. Sestan (Author/Creator)
N. Jahanshad (Author/Creator)
L. Ding (Author/Creator)
W.S. Kremen (Author/Creator)
C.E. Franz (Author/Creator)
N.A. Gillespie (Author/Creator)
S. Debette (Author/Creator)
S. Maingault (Author/Creator)
A. Mishra (Author/Creator)
C. Tzourio (Author/Creator)
H.J. Grabe (Author/Creator)
R. Bülow (Author/Creator)
K. Wittfeld (Author/Creator)
S. van der -Palitschka (Author/Creator)
S. Frenzel (Author/Creator)
M.A. Ikram (Author/Creator)
H.H.H.H. Adams (Author/Creator)
T.E. Evans (Author/Creator)
N. Terzikhan (Author/Creator)
P.S. Sachdev (Author/Creator)
W. Wen (Author/Creator)
H. Brodaty (Author/Creator)
M.J. Wright (Author/Creator)
J.N. Trollor (Author/Creator)
A. Thalamuthu (Author/Creator)
P.R. Schofield (Author/Creator)
J.B. Kwok (Author/Creator)
J. Jiang (Author/Creator)
D. Ames (Author/Creator)
K.A. Mather (Author/Creator)
N.J. Armstrong (Author/Creator)
A. Villringer (Author/Creator)
F. Beyer (Author/Creator)
A.V. Witte (Author/Creator)
M. Loeffler (Author/Creator)
M. Scholz (Author/Creator)
I.E. Deary (Author/Creator)
J.M. Wardlaw (Author/Creator)
M.A. Harris (Author/Creator)
M.E. Bastin (Author/Creator)
L. Lewis (Author/Creator)
S. Karama (Author/Creator)
M. Luciano (Author/Creator)
Q. Yang (Author/Creator)
S. Li (Author/Creator)
J.C. Bis (Author/Creator)
B. Mazoyer (Author/Creator)
F. Crivello (Author/Creator)
A. Carrion-Castillo (Author/Creator)
H. Schmidt (Author/Creator)
R. Schmidt (Author/Creator)
L. Pirpamer (Author/Creator)
Y. Saba (Author/Creator)
M. Fornage (Author/Creator)
T.H. Mosley (Author/Creator)
R. Gottesman (Author/Creator)
X. Jian (Author/Creator)
A.M.M. Sousa (Author/Creator)
G.V. Roshchupkin (Author/Creator)
S. Tilley (Author/Creator)
D.E. Vosberg (Author/Creator)
Y. Patel (Author/Creator)
E. Hofer (Author/Creator)
S. Ma (Author/Creator)
J. Shin (Author/Creator)
Publication Details: Cerebral Cortex, Vol.30(7), pp.4121-4139
Publisher: Oxford Academic
Identifiers: 991005540626207891
Copyright: © The Author(s) 2020.
Murdoch Affiliation: Information Technology, Mathematics and Statistics
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

57 Record Views

17 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.455 Genome-Wide Association Studies
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior