Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

L. Smart; E. Bosio; S.P.J. Macdonald; R. Dull; D.M. Fatovich; C. Neil; G. Arendts

doi:10.1016/j.jcrc.2018.06.015

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Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

Journal article

Peer reviewed

Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

L. Smart, E. Bosio, S.P.J. Macdonald, R. Dull, D.M. Fatovich, C. Neil and G. Arendts

Journal of Critical Care, Vol.47, pp.93-98

2018

DOI: https://doi.org/10.1016/j.jcrc.2018.06.015

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Abstract

Purpose Endocan, a component of the endothelial glycocalyx (EG), has been linked with respiratory failure in sepsis. This study explored the temporal patterns of three EG biomarkers, including endocan, and their relationships with inflammation and respiratory failure. Materials and methods Plasma endocan, syndecan-1, and hyaluronan concentrations were measured in Emergency Department (ED) patients with sepsis due to pneumonia (n = 44) on ED arrival (T0), 1 h (T1), 3 h (T3) and 12–24 h (T24) later, with change over time tested using mixed regression models. Biomarker associations with inflammatory cytokine concentrations and with respiratory failure on days 1, 2 or 3, need for mechanical ventilation and 30-day mortality were also tested. Results Endocan concentration significantly decreased over time (T0–T24, P = 0.003) whereas both syndecan-1 (T0–T3, P = 0.010; T0–T24, P < 0.001) and hyaluronan (T0–T1, P = 0.010; T0–T3, P < 0.001; T0–T24, P = 0.003) significantly increased over time. Increased syndecan-1 was significantly correlated with neutrophil activation biomarkers and significantly increased the odds of respiratory failure (OR 1.18, 95% CI 1.05–1.33, P = 0.004), need for mechanical ventilation (OR 1.24, 95% CI 1.04–1.48, P = 0.014) and 30-day mortality (OR 1.29, 95% CI 1.07–1.55, P = 0.008). Conclusion Syndecan-1, but not endocan, was associated with neutrophil activation and was the best EG biomarker predictor of adverse clinical outcomes.

Details

Title: Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan
Authors/Creators: L. Smart (Author/Creator) - Harry Perkins Institute of Medical Research
E. Bosio (Author/Creator) - Harry Perkins Institute of Medical Research
S.P.J. Macdonald (Author/Creator) - Harry Perkins Institute of Medical Research
R. Dull (Author/Creator) - Illinois College
D.M. Fatovich (Author/Creator) - Harry Perkins Institute of Medical Research
C. Neil (Author/Creator) - Harry Perkins Institute of Medical Research
G. Arendts (Author/Creator) - Harry Perkins Institute of Medical Research
Publication Details: Journal of Critical Care, Vol.47, pp.93-98
Publisher: Elsevier B.V.
Identifiers: 991005542314707891
Copyright: © 2018 Published by Elsevier Inc.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.239 Tissue Barriers; 1.239.1358 Blood-Brain Barrier
Web Of Science research areas: Critical Care Medicine
ESI research areas: Clinical Medicine